Innovative Cancer Models (Details)

Innovative Cancer Models

Dr. Martin Distel (PhD)

Email: martin.distel(at)ccri.at

Team Innovative Cancer Models

Research Focus

Our research focus is on the generation of pediatric cancer models in zebrafish to better understand tumor initiation and tumor progression on a cellular and molecular level.

Zebrafish platform Austria for preclinical drug screening (ZANDR)

ZANDR Symposium 11th October 2019: Schedule ZANDR Symposium The ZANDR platform (Danio4Can Project) received funding by the FFG´s 1st Infrastructure Funding Call (2016).

We use zebrafish (danio rerio) to model pediatric cancers (leukemia and solid tumors) and rare cancer predisposition syndromes. Using cutting-edge genetic modeling approaches combined with state of the art in vivo imaging we aim to dissect the molecular mechanisms, which govern tumor onset and tumor progression. Our genetic models are also employed in our lab for drug screening to identify potential therapeutic strategies. We further use our models to better understand the role of the innate immune system at early tumor initiating stages. In an alternative modeling approach, we explore the use of patient derived xenograft models in zebrafish (PDXz) to predict disease progression and to evaluate therapeutic compounds.
Selected Articles Pascoal S, Salzer B, Scheuringer E, Wenninger-Weinzierl A, Sturtzel C, Holter W, Taschner-Mandl S, Lehner M, Distel M. A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Cancers (Basel). 2020 Feb 29;12(3). pii: E567. doi: 10.3390/cancers12030567. Mayr V, Sturtzel C, Stadler M, Grissenberger S, Distel M. Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish. Front Cell Dev Biol. 2018 Sep 25;6:111. doi: 10.3389/fcell.2018.00111. eCollection 2018. Distel M. Wullimann M. & Köster R.W. (2009) Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13365-70. Kainrath S, Stadler M, Reichhart E, Distel M, Janovjak H.(2017) Green-Light-Induced Inactivation of Receptor Signaling Using Cobalamin-Binding Domains. Angew Chem Int Ed Engl. 2017 Mar 20. doi: 10.1002/anie.201611998. Kirchberger S, Sturtzel C, Pascoal S and Distel M (2017) Quo natas, Danio?-Recent Progress in Modeling Cancer in Zebrafish. Front. Oncol. 7:186. doi: 10.3389/fonc.2017.00186. Alghisi E, Distel M, Malagola M, Anelli V, Santoriello C, Herwig L, Krudewig A, Henkel CV, Russo D, Mione MC. (2013) Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the Notch pathway. Leukemia 2229-41. doi: 10.1038/leu.2013.132. Epub 2013 Apr 29 Walker S.L., Ariga J., Mathias J.R., Coothankandaswamy V., Xie X., Distel M., Köster R.W., Parsons M.J., Bhalla K.N., Saxena M.T., Mumm J.S. (2012) Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS One. 2012;7(1):e29916 Distel M. Wullimann M. & Köster R.W. (2009) Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13365-70.

Team Innovative Cancer Models

Dr. Martin Distel (PhD)

Dr. Martin Distel (PhD)

Group Leader

martin.distel(at)ccri.at +43 1 40470 4010

Stefanie Kirchberger, PhD

Stefanie Kirchberger, PhD

Postdoctoral Fellow

stefanie.kirchberger(at)ccri.at +43 1 40470 4011

Caterina Sturtzel, PhD

Caterina Sturtzel, PhD

"Zebrafish platform Austria for preclinical drug screening" Operator

caterina.sturzel(at)ccri.at +43 1 40470 4011
Sarah Grissenberger, MSc

Sarah Grissenberger, MSc

PhD student

sarah.grissenberger(at)ccri.at +43 1 40470 4011
Adam Varady, MSc

Adam Varady, MSc

PhD student

adam.varady(at)ccri.at +43 1 40470 4011
Andrea Wenninger-Weinzierl

Andrea Wenninger-Weinzierl

Technician

andrea.wenninger-weinzierl(at)ccri.at +43 1 40470 4011
Eva Scheuringer

Eva Scheuringer

ZANDR Operator

eva.scheuringer(at)ccri.at +43 1 40470 4013
Benjamin Natha, BSc

Benjamin Natha, BSc

Lead Aquatic Technician

benjamin.natha(at)ccri.at +43 1 40470 4013

Affiliated Clinicians

Assoc. Prof. Dr. Leo Kager, MD

Pharmaceuticals, Special Issue: Zebrafish as Platform for Preclinical Compound Screening

zebrafish_screening-flyer