Post-Doctoral Researcher - Computational Analysis of Pediatric Cancer

Post-Doctoral Researcher - Computational Analysis of Pediatric Cancer

The newly established research group “Integrative Analysis of Pediatric Cancer” headed by Florian Halbritter, at the Children’s Cancer Research Institute (CCRI) is looking to for a post-doctoral researcher to join our quest to take apart childhood cancer. We are looking for highly motivated and self-driven individuals who are keen to employ their skills to make a difference. Ideally, you will already have an extensive track record working with high-throughput biological data and have shown the ability to translate these data into meaningful insights. We value ingenuity and are open for new approaches and perspectives. In exceptional cases, experienced experimental researchers may be considered for the post. You will work in close collaboration with molecular biologists, geneticists, oncologists, and bioinformaticians locally and internationally, so good interpersonal skills and a willingness to apply them are essential.

You will:

  • Take on ambitious research in close collaboration with experimental and clinical researchers. You will contribute from the start including planning of experiments and data acquisition, and guide the project to a successful finish by providing thorough and creative analysis
  • Use data from state-of-the-art technologies, including but not limited to high-throughput sequencing. You see technologies as tools and are keen to use the latest and best
  • Monitor the literature, latest software tools, and community resources to keep abreast current developments and to identify information, data, and methods to integrate in your own work
  • Write papers, visit conferences, present your research, review papers, apply for fellowships, and contribute to grants

Your qualifications:

  • PhD in bioinformatics, biostatistics, or data science applied to biomedicine, or alternatively a PhD in molecular biology with additional experience
  • Experience with high-throughput data analysis, ideally including several of the following: (single-cell and/or bulk) RNA-seq, ATAC-seq, ChIP-seq, WGBS/RRBS
  • Good programming and/or scripting skills (R and/or Python)
  • Pragmatic understanding of statistics, good numeric skills, and sound logic
  • Good verbal and written communication / presentation skills (in English, German not required)
  • Prior experience with (pediatric) cancer is a plus, but not required
  • Ability to work thoroughly and independently
  • An exceptional level of enthusiasm, creativity and determination

Projects: We aim to investigate the molecular framework underlying different types of cancer to find new markers for improved diagnostics and targets for therapy. Own project ideas fitting within the scope of the CCRI are encouraged. Current projects include:

  • Dissecting intratumor heterogeneity with single-cell transcriptomics and multi-scale epigenomics
  • Utilizing epigenomic readouts of liquid biopsies to monitor treatment response in solid tumors
  • Identifying molecular predictors of relapse in childhood leukemia based on DNA methylation
  • In-vitro and computational modeling of developmental diseases
  • Development of user-friendly tools for visual analysis and interpretation of epigenomes

The institution: The CCRI is situated in the center of Vienna, one of Europe’s most important places for medical research and life sciences and cited as the most livable city in the world. As a vibrant, international environment, it hosts about 100 researchers working on pediatric leukemia, solid tumors, immunology, and stem cell transplantation. Tightly associated with St. Anna Children´s Hospital, the biggest center for pediatric hematology and oncology in Austria and one of the leading treatment centers for children with cancer in Europe, the CCRI performs basic, translational, and clinical research. Genomics and epigenomics of pediatric cancers are areas of strategic development on its way to precision medicine. Your application: Successful applicants will be offered a salary according to the Austrian Science Fund FWF; and a contract for up to three years with a possibility of extension. Applications should include a motivation letter, curriculum vitae, annotated list of publications, and contact details of three references. Feel free to include any other information, links, or materials that you believe are relevant to your application. Please send your application only per e-mail: hr(at) to Florian Halbritter. The position shall be staffed as soon as possible, there is currently no fixed closing date for incoming applications.