The Children’s Cancer Research Institute - CCRI (St. Anna Kinderkrebsforschung) is Austria’s leading center for research aimed at advancing the diagnosis and treatment of children’s cancer. It pursues an ambitious basic, translational and clinical research program, including areas such as cancer biology, immunology, and genetics/epigenetics (http://science.ccri.at). CCRI is part of a flourishing biomedical research hub at the heart of Vienna. It is a renowned research institution with tight links to the St. Anna Children’s Hospital, a leading pediatric cancer center in Europe that is internationally well-connected through European and global networks.
The focus of our group (lead by Prof. Kaan Boztug) is to identify novel gene defects that lead to rare disorders of the immune system and to further functionally analyze their impact on the severe pathophysiologic manifestations in patients. (Kager L et al. Br J Haematol. 2018, Ozen A et al. NEJM 2017, Salzer E et al. Nat Immunol 2016, Dobbs K et al. NEJM 2015, Boztug K at al. Nat Genet 2014). In addition, we are establishing a research program on precision oncology medicine focusing on childhood cancer.
In the context of this work, we apply a combination of state-of-the-art genetic and genomic technologies including next generation sequencing, and a wide range of cellular and molecular techniques to elucidate novel pathways important for immune system homeostasis.
We are looking for a highly motivated and well-organized
with a strong interest in genetics and research of rare and undiagnosed diseases. The candidate will be integrated into the genetics core of the institute with the emphasis on genomic technologies leading to identification of disease-causing mutations. In this position, you will substantially contribute to the infrastructure, operation of the lab and documentation. We have established a streamlined workflow for NGS-based genetic analyses that requires continuous maintenance and optimization as well as development and implementation of novel assays, tools and infrastructure.
- Isolation and culturing of peripheral blood mononuclear cells (PBMCs) and nucleic acid isolation from human samples
- PCR (including primer design and analysis) and conventional (Sanger) sequencing
- Next generation sequencing-based methods (including exome sequencing, genome sequencing, RNAseq and potentially others)
- Interpretation, reporting and documentation of genetic findings into a local database
- Contribution to lab management (e.g. ordering, preparation of general reagents)
Requirements and desired qualifications:
- Bachelor or Master degree in Life Sciences, Biomedical Analyst or a TA/MTA Diploma
- Previous experience in genetics, molecular biology and/or cellular techniques
- High accuracy and sense of responsibility
- Excellent interpersonal and organization skills
- Ability to work in an international environment
- Written and oral communication skills in English
- a challenging position in a meaningful, inspiring, and international setting
- an excellent working atmosphere in a strong team with flat hierarchy
- the competitive salary starts with € 2.700,-- gross (paid 14 times per year), but of course taking into account your specific background and qualification a higher salary is possible.
Applications including motivation letter describing your career goals and explaining why you are the ideal candidate for this position and your curriculum vitae should be sent by e-mail firstname.lastname@example.org to Doris Gangl. Initial application deadline is end of August 2019, but applications will be reviewed and the call will remain open until the position is filled. Start date is flexible.