Alumni

Alumni

Postdoctoral fellows, PhD and diploma students at the CCRI

Completed theses

PhD Theses

Stephanie Anderl
The role of PAX5 fusion genes in the pathogenesis of childhood B-cell precursor acute lymphoblastic leukemia.
PhD Thesis
Supervised by Sabine Strehl, PhD and Klaus Fortschegger, PhD

Amedeo Azizi
Simian Virus 40 and the Human Polyomaviruses JCV and BKV in the Cerebrospinal Fluid of Paediatric Brain Tumor Patients.
PhD Thesis
Supervised by Prof. Irene Slavc, MD, Univ. Kinderklinik and Prof. Prof. Oskar A. Haas, MD

Radostina Bachmaier
Post-translational modifications of the Ewing´s Tumor oncoprotein EWS-FLI1.
PhD Thesis
Supervised by Prof. Heinrich Kovar, PhD

Sara Colomer-Lahiguera
The role of CDKN1B-p27kip1 deregulation in the pathogenesis of pediatric T-cell acute Lymphoblastic Leukemia.
PhD Thesis
Supervised by Sabine Strehl, PhD

Dagmar Denk
The role of PAX5 fusion genes in childhood acute lymphoblastic leukemia.
PhD Thesis
Supervised by Sabine Strehl, PhD

Alexander M. Dohnal
Anti leukemia-specific humoral immune response in children with T-lineage acute lymphoblastic leukemia.
PhD Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

Karin Ebner
Rolle von Adenoviren bei malignen Tumoren.
PhD Thesis
Supervised by Prof. Thomas Lion, MD, PhD

Karin Fasching
Leukemia clone specific antigen receptor gene rearrangements.
PhD Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

M. Fink
RET- Mutationsuntersuchungen. "Molecular genetic analysis of the RET proto-oncogene in sporadic and herditary medullary thyroid carcinoma."
PhD Thesis
Supervised by Prof. Oskar A. Haas, MD

Ursula Hainz
The role of tryptophan catabolism in T-cell regulation after hematopoietic stem cell transplantation.
PhD Thesis
Supervised by Assoc. Prof. Andreas Heitger, MD

Klaudia Hettinger
Antigen receptor gene rearrangements in childhood acute lymphoblastic leukemia.
PhD Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

E. Hörth
Dynamics of Expression of the human Leukemia-associated fusion gene BCR/ABL.
PhD Thesis
Supervised by Prof. Thomas Lion, MD, PhD

Susanne Hübner
Antigen receptor gene rearrangements in children with acute lymphoblastic leukemia: implications for the biology of the disease.
PhD Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

Katharina Hüttner
Development of a mouse model for anti-tumor immune therapy – basic research in vitro and first applications in vivo.
PhD Thesis
Supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Andrea Inthal
The erythropoietin receptor (EPOR) and t(12;21) positive acute lymphoblastic leukemia.
PhD Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

Birgit Jürgens
The immunomodulatory mechanisms of indoleamine 2,3-dioxygenase (IDO) in human allo-reactivity.
PhD Thesis
Supervised by Assoc. Prof. Andreas Heitger, MD

Agata Kowalska
Linkage of chromosomal sequence information enables mapping of chromosomal expression profile of senescent neuroblastoma cells.
PhD Thesis
Supervised by Assoc. Prof. Peter F. Ambros, PhD

Gerd Krapf
The molecular function of ETV6/RUNX1 in t(12;21) positive acute Lymphoblastic leukaemia.
PhD Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

Michael Kreppel
A role for CD99 in Ewing´s sarcoma family tumors: By modulating KCMF1 CD99 is involved in the migratory ability of Ewing´s sarcoma cells.
PhD Thesis
Supervised by Prof. Heinrich Kovar, PhD

Franciska Leberl
CD34 Subpopulationen in peripherem Blut und Knochenmark und deren Differenzierungsverhalten in vitro”.
PhD Thesis
Supervised by Assoc. Prof. Gerhard Fritsch, PhD

Manfred Lehner
Responses of dendritic cells to factors released during viral and bacterial infection and to physiologic signals during interaction with T-cells.
PhD Thesis
Supervised by Prof. Wolfgang Holter, MD, PhD

Mareike Lindbauer
IDO: a target for improving anti-tumour immunity.
PhD Thesis
Supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Peter Mikl
The in vitro and in vivo expression of the cytolytic protein Perforin.
PhD Thesis
Supervised by Prof. Wolfgang Holter, MD, PhD

B. Mossier
Identification of genomic DNA sequences and cellular proteins interacting with the FLI1 domain of oncogenic EWS/FLI1 in Ewing tumor cells.
PhD Thesis
Supervised by Prof. Kovar, PhD

Rita Narath
Quantification of revertant tumor cells in MYCN amplified neuroblastoma cell lines.
PhD Thesis
Supervised by Assoc. Prof. Peter F. Ambros, PhD

Karin Nebral
Detection and characterization of PAX5 aberrations in childhood acute lymphoblastic leukemia.
PhD Thesis
Supervised by Sabine Strehl, PhD

Christine Siligan
Isolation of EWS-FLI1 target genes in Ewing´s sarcoma.
PhD Thesis
Supervised by Prof. Heinrich Kovar, PhD

Christian Skarits
Quantitation of LDL (apoB/E) receptor, HMG-CoA reductase, SREBP-1a, -1c, and –2 mRNA in peripheral blood mononuclear cells from patiets with acute myelogeneous leukemia and juvenile myelomonocytic leukemia by competitive RT-PCR.
PhD Thesis
Supervised by Prof. Oskar A. Haas, MD

Laura Spahn
Cellular protein interaction partners for the oncogenic transcription factor EWS-FLI1: Delineation of the interaction surface with hsRPB7 and characterization of the communication with the tumor suppressor BARD1.
PhD Thesis
Supervised by Prof. Heinrich Kovar, PhD

Manuel Steiner
Reactivations in Langerhans cell histiocytosis.
PhD Thesis
Supervised by Assoc. Prof. Milen Minkov, MD and Prof. Prof. Helmut Gadner, MD, MD

F. Stolz
Minimal residual disease in childhood acute lymphoblastic leukemia.
PhD Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

Franz Watzinger
Innovative Approaches to nucleid acid – quantification via polymerase-chain reaction.
PhD Thesis
Supervised by Prof. Thomas Lion, MD, PhD

Martha Wnorowski
Pattern and Course of neurodegenerative Langerhans cell Histiocytosis.
PhD Thesis
Supervised by Nicole Grois, MD, and Prof. Helmut Gadner, MD

Petra Zeitlhofer
X Chromosome Nondisjunction and Inactivation Mechanisms in Childhood Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin Lymphoma (NHL).
PhD Thesis
Supervised by DI Andreas Weinhäusel, PhD, and Prof. Oskar A. Haas, MD

MD Theses

R. Crazzolara
Der Chemokin Rezeptor CXCR-4 wird auf Blasten der kindlichen akuten lymphatischen Leukämie exprimiert und ist funktionell aktiv: mögliche Rolle in der Organinfiltration.
MD Diploma Thesis
Supervised by Prof. Dr. B. Meister

Friedrich Erhardt
The molecular biology of dendritic cells and their application in cell therapy.
MD Diploma Thesis
Supervised by Assoc. Prof. Thomas Felzmann, MD, MBA
Co-supervised by Alexander M. Dohnal, PhD

A. Heise
Langerhanszellhistiozytose im Kindesalter – eine Untersuchung zu Krankheitsverlauf und Spätfolgen in Abhängigkeit von der initialen Therapie an 421 Patienten aus Deutschland, Österreich, der Schweiz und den Niederlanden.
MD Diploma Thesis
Supervised by Prof. Helmut Gadner, MD

Sabine Heitzeneder
Mutation analysis of mannan binding lectin deficiency examined by denaturing high performance liquid chromatography.
MD Diploma Thesis
Supervised by Assoc. Prof. Andreas Heitger, MD

A. Leithner
Aneurysmale Knochenzysten. New aspects in the pathogenesis of aneurysmal bone cysts.
MD Diploma Thesis
Supervised by Prof. Oskar A. Haas, MD

Barbara Moritz
Phenotypic and functional aspects of dendritic cell regeneration after bone marrow and stem cell transplantation.
MD Diploma Thesis
Supervised by Assoc. Prof. Andreas Heitger, MD

N. Moughrabi
Akzeptanz, Durchführung und Qualität des Strahlentherapeutischen Teiles der multizentrischen Studie DAL-HD-90.
MD Diploma Thesis
Supervised by Prof. Helmut Gadner, MD H

Helmut Prosch
Methods to determine telomerase activity and teleomer length: methodological aspects and clinical relevance.
MD Diploma Thesis
Supervised by Prof. Thomas Lion, MD, PhD

Edda Unger
Permanent consequences in patients with Langerhans cell histiocytosis with focus on neuro psychological findings.
MD Diploma Thesis
Supervised by Nicole Grois, MD, and Prof. Helmut Gadner, MD

MSc Theses

Heide-Maria Binder
Time dependent changes during hydroxyurea induced senescence in MYCN amplified Neuroblastoma.
MSc Diploma Thesis
Supervised by Assoc. Prof. Peter F. Ambros, PhD

Dominik Bogen
Heterogeneous MYCN amplification in neuroblastoma – amplicon, genomic background and genome instability.
MSc Diploma Thesis
Supervised by Assoc. Prof. Peter F. Ambros, PhD

Christina Freimüller
Low influence of irradiation on the functional activity of in-vitro expanded ADV-specific T-cells: A safe and potential therapeutic option for adoptive immunotherapy.
MSc Diploma Thesis
Supervised by René Geyeregger, PhD
Co-supervised by Prof. Heinrich Kovar, PhD

Angela Halfmann
Characterization of a PHD finger family transcription factor by siRNA targeting of dendritic cells.
MSc Diploma Thesis
Supervised by Alexander M. Dohnal, PhD.
Co-supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

K. Hettinger
TCR gamma and delta rearrangements for the detection of minimal residual disease in T-lineage acute lymphoblastic leukemia.
MSc Diploma Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

Ruth Joas
Identification of cellular proteins interacting with the CD99/MIC2 transmembrane protein using the Yeast Two-Hybrid System.
MSc Diploma Thesis
Supervised by Prof. Heinrich Kovar, PhD

Birgit Jürgens
Studies on a possible cooperation of interleukin-10 and rapamycin on the induction of tolerance in a human mixed lymphocyte reaction.
MSc Diploma Thesis
Supervised by Assoc. Prof. Andreas Heitger, MD

Linda Krempl
Down-modulation of T-cell responsiveness induced by human IDO competent dendritic cells.
MSc Diploma Thesis
Supervised by Assoc. Prof. Andreas Heitger, MD

Romana Luger
Etablierung eines Mausmodels für die Intratumorale Injektion von reifenden, IL-12 produzierenden Dendritischen Zellen.
MSc Diploma Thesis
Supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Wiebke Mensing
Elucidating the role of PTEN and its pseudogene PTENP1 in the pathogenesis of T-cell acute lymphoblastic leukemia
MSc Diploma Thesis
Supervised by Sabine Strehl, PhD

Ulrike Nagl
Inhibition of Adenoviruses by enzyme-dependent activation of prodrugs.
MSc Diploma Thesis
Supervised by Reinhard Klein, PhD, working group of Prof. Thomas Lion, MD, PhD

Karin Nebral
Detection and characterization of NUP98 rearrangements in hematopoietic malignancies.
MSc Diploma Thesis
Supervised by Sabine Strehl, PhD and Prof. Oskar A. Haas, MD

Stefan Niedan
Role of hypoxia and hypoxia inducible factors (HIFs) in cells of Ewing’s sarcoma family tumours.
MSc Diploma Thesis
Supervised by Prof. Heinrich Kovar, PhD

Heide Niederleitner
Detection of a proposed preleukemic clone in patients with TEL-AML1 positive ALL.
MSc Diploma Thesis
Supervised by Prof. Renate E. Panzer-Grümayer, MD

Petra Paul
The cellular biology of cross-presentation: Two-step maturation of dendritic cells.
MSc Diploma Thesis
Supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Dagmar Pfeiffer
Transcriptional regulation of H-ras by p53.
MSc Diploma Thesis
Supervised by Prof. Heinrich Kovar, PhD

Teresa Preglej
Identification and characterization of intragenic PAX5 amplifications in childhood B-cell precursor acute lymphoblastic leukemia
MSc Diploma Thesis
Supervised by Sabine Strehl, PhD and Klaus Fortschegger, PhD

Sandra Preuner
Development of novel methodological approaches to detection and quantitative monitoring of point-mutated clones.
MSc Diploma Thesis
Supervised by Prof. Thomas Lion, MD, PhD

Margit Rauch
Latent Adenovirus Infections in Primary Human T-cells.
MSc Diploma Thesis
Supervised by Karin Kosulin, PhD (working Group of Prof. Thomas Lion, MD, PhD, MSc)

Jürgen Reisinger
Fine-mapping of the episomal and intergrated Epstein-Barr virus (EBV) genome in the Burkitt’s lymphoma cell line DAUDI and NAMALWA and in the lymphoblastoid cell line MD-10.
MSc Diploma Thesis
Supervised by Assoc. Prof. Peter F. Ambros, MD

Claus Schermann
Investigations into the quantitative analysis of antigen-specific lymphocytes by flow cytometry.
MSc Diploma Thesis
Supervised by Assoc. Prof. Gerhard Fritsch, PhD

Sabine Schmidhuber
Influence of RNAi-mediated EWS-FLI1 modulation on its putative down-stream targets in Ewing tumor cells.
MSc Diploma Thesis
Supervised by Prof. Heinrich Kovar, PhD

Cornelia Schuh
Immune suppressive mechanisms in toll-like-receptor 4 (TLR4) kinase family member in dendritic cells.
MSc Diploma Thesis
Supervised by Alexander M. Dohnal, PhD.
Co-supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Elisabeth Schraml
Analysis of chimerism by STR-PCR after allogeneic stem cell transplantation: approaches to quantification and standardization of methods.
MSc Diploma Thesis
Supervised by Prof. Thomas Lion, MD, PhD

Raphaela Schwentner
Molecular Mechanisms of Transcriptional Repression by the EWS-FLI1 Oncogene in Ewing´s sarcoma.
MSc Diploma Thesis
Supervised by Prof. Heinrich Kovar, PhD

Michael Traxlmayr
Immune-suppressive V?9Vd2 T cells as a novel regulatory mechanism modulated by IL-12 secreting dendritic cells.
MSc Diploma Thesis
Supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Sneha Valookaran
Importance of timing in immune modulation. A study on toll like receptor-4 activated dendritic cells.
MSc Diploma Thesis
Supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Sarah Vittori
Characterization of a putative immunosuppressive MAPKAP kinase family member in dendritic cells.
MSc Diploma Thesis
Supervised by Alexander M. Dohnal, PhD.
Co-supervised by Assoc. Prof. Thomas Felzmann, MD, MBA

Alexander Zimmerhackl
Rolle von Polyoma-Viren bei malignen Tumoren.
MSc Diploma Thesis
Supervised by Prof. Thomas Lion, MD, PhD

Other Theses

Madeleine Fichtinger
Klinische Studien an (krebskranken) Minderjährigen unter besonderer Bedachtnahme der ethischen Aspekte und der Versicherung des medizinischen Risikos.
Doctoral thesis to obtain the university degree of Doctor of Law
Supported by Assoc. Prof. Ruth Ladenstein, MD, MBA, cPM

Daniela Krehan
PAX5 aberrations in childhood acute lymphoblastic leukemia.
FH Diploma Thesis (FH Campus Vienna, Biotechnology)
Supervised by Sabine Strehl, PhD

Margit Lanzinger
The immunosuppressive potential of indoleamine 2,3-dioxygenase in human allo-reactivity and its limitations.
Dipl.-Ing. Diploma Thesis
Supervised by Assoc. Prof. Andreas Heitger, MD

Michael Traxlmayr, Dipl.-Ing. Dr.

Postdoc at Massachusetts Institute of Technology (MIT), Koch Institute for Integrative Cancer Research

I got the opportunity to do my master thesis at the CCRI under the supervision of Thomas Felzmann and Alexander Dohnal. I extremely enjoyed my time there, not only because of working on an interesting project, but also because of having great colleagues, who were always helpful and spread a highly enjoyable working atmosphere. The people at CCRI clearly aroused my enthusiasm for science, which has never stopped since then.

PD Dr. Adelheid Cerwenka

Head of the Boveri Junior Research Group ‘Innate Immunity’ at the German Cancer Research Centre (DKFZ)

Adelheid Cerwenka studied pharmacy at the University of Vienna and received her PhD in immunology, working primarily at the Institute of Immunology, the CCRI and the St. Anna Children´s hospital, under supervision of Prof. Knapp and Prof. Holter. After several years as a post-doc at the University of California and the DNAX research institute, she returned to Vienna and became head of the division of autoimmune diseases at the Novartis research institute. PD Dr. Adelheid Cerwenka has been leading the Boveri Junior Research Group ‘Innate Immunity’ at the German Cancer Research Centre (DKFZ) since 2003. In 2009, she was awarded the Georges Köhler Prize for outstanding research achievements, studying natural killer cells and their importance in combating tumours.

Mag. Dr. Friedrich Erhart

Research intern at the Center of Molecular Medicine of the Austrian Academy of SciencesCeMM

"My time at the St. Anna Children's Cancer Research Institute (CCRI) was an absolutely inspiring experience. During my medical studies I did research here on Dendritic Cells under the supervision of Thomas Felzmann and Alexander Dohnal. It was great to do immunology in theory and practice and participate in a project that is linking lab research and clinical application very closely. Not only were all the people I met at CCRI highly professional, they were also tremendously helpful and great to work with."

Jan Trka, M.D., Ph.D

Professor of Medical Genetics, Head - Laboratory Centre CLIP – Childhood Leukaemia Investigation Prague, Charles University Prague Czech Republic

“I spent an exciting time at CCRI in 1994 during my PhD studies on fusion genes BCR/ABL and MLL/AF4 under the supervision of Prof. Thomas Lion, who played a crucial role in the start of my research carrier and with whom I also published my first two papers as a senior author. CCRI served as a “blueprint” for the development of the Laboratory Centre of our Department in Prague. Moreover, at CCRI I met a group of important scientists in the field whom I regularly meet and collaborate with till now.”

Prof. Angelika Berger, MD, MBA

Professor of Child and Adolescent Medicine Division of Neonatology, Pediatric Intensive Care and Neuropediatrics Department of Pediatrics and Adolescent Medicine Medical University Vienna

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Dr. Markus Horcher

Director Quality & Project Management Office at Borealis AG, Austria

Dr. Markus Horcher collaborated with Prof. Thomas Felzmann at CCRI in 1999/2000 during his civil servant/Zivildiener service, on the development of an immune therapeutic for the treatment of pediatric cancer based on IL-12 producing dendritic cells for the activation of cytotoxic T cells. After concluding his research at CCRI he went on to become a Consultant at McKinsey & Company, Inc. for the next four years.