Publications 2017

Abbasi, M.R., Rifatbegovic, F., Brunner, C., Mann, G., Ziegler, A., Potschger, U., Crazzolara, R., Ussowicz, M., Benesch, M., Ebetsberger-Dachs, G., Chan, G.C., Jones, N., Ladenstein, R., Ambros, I.M., Ambros, P.F., 2017. Impact of disseminated neuroblastoma cells on the identification of the relapse-seeding clone. Clin Cancer Res.

Amoroso, L., Erminio, G., Makin, G., Pearson, A.D., Brock, P., Valteau-Couanet, D., Castel, V., Pasquet, M., Laureys, G., Thomas, C., Luksch, R., Ladenstein, R., Haupt, R., Garaventa, A., Group, S., 2017. Topotecan-Vincristine-Doxorubicin in Stage 4 High Risk Neuroblastoma Patients Failing to Achieve a Complete Metastatic Response to Rapid COJEC - a SIOPEN Study. Cancer Res Treat.

Bileck, A., Mayer, R.L., Kreutz, D., Weiss, T., Taschner-Mandl, S., Meier, S.M., Slany, A., Gerner, C., 2017. Evaluation of inflammation-related signaling events covering phosphorylation and nuclear translocation of proteins based on mass spectrometry data. J Proteomics 152, 161-171.

Creutzig, U., Dworzak, M.N., Bochennek, K., Faber, J., Flotho, C., Graf, N., Kontny, U., Rossig, C., Schmid, I., von Stackelberg, A., Mueller, J.E., von Neuhoff, C., Reinhardt, D., von Neuhoff, N., 2017. First experience of the AML-Berlin-Frankfurt-Munster group in pediatric patients with standard-risk acute promyelocytic leukemia treated with arsenic trioxide and all-trans retinoid acid. Pediatr Blood Cancer.

Dworzak, M.N., Buldini, B., Gaipa, G., Ratei, R., Hrusak, O., Luria, D., Rosenthal, E., Bourquin, J.P., Sartor, M., Schumich, A., Karawajew, L., Mejstrikova, E., Maglia, O., Mann, G., Ludwig, W.D., Biondi, A., Schrappe, M., Basso, G., International, B.F.M.F.n., 2017. AIEOP-BFM consensus guidelines 2016 for flow cytometric immunophenotyping of Pediatric acute lymphoblastic leukemia. Cytometry B Clin Cytom.

Gardiner, J.D., Abegglen, L.M., Huang, X., Carter, B.E., Schackmann, E.A., Stucki, M., Paxton, C.N., Randall, R.L., Amatruda, J.F., Putnam, A.R., Kovar, H., Lessnick, S.L., Schiffman, J.D., 2017. C/EBPbeta-1 promotes transformation and chemoresistance in Ewing sarcoma cells. Oncotarget.

He, T., Surdez, D., Rantala, J.K., Haapa-Paananen, S., Ban, J., Kauer, M., Tomazou, E., Fey, V., Alonso, J., Kovar, H., Delattre, O., Iljin, K., 2017. High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability. Gene 596, 137-146.

Husak, Z., Dworzak, M.N., 2017. Chronic stress induces CD99, suppresses autophagy, and affects spontaneous adipogenesis in human bone marrow stromal cells. Stem Cell Research & Therapy 8, 83.

Kainrath, S., Stadler, M., Reichhart, E., Distel, M., Janovjak, H., 2017. Green-Light-Induced Inactivation of Receptor Signaling Using Cobalamin-Binding Domains. Angew Chem Int Ed Engl.

Kolenová, A., Schwentner, R., Jug, G., Simonitsch-Klupp, I., Kornauth, C., Plank, L., Horáková, J., Bodová, I., Sýkora, T., Geczová, L., Holter, W., Minkov, M., Hutter, C., 2017. Targeted inhibition of the MAPK pathway: emerging salvage option for progressive life-threatening multisystem LCH. Blood Advances 1, 352-356.

Ladenstein, R., Potschger, U., Pearson, A.D., Brock, P., Luksch, R., Castel, V., Yaniv, I., Papadakis, V., Laureys, G., Malis, J., Balwierz, W., Ruud, E., Kogner, P., Schroeder, H., de Lacerda, A.F., Beck-Popovic, M., Bician, P., Garami, M., Trahair, T., Canete, A., Ambros, P.F., Holmes, K., Gaze, M., Schreier, G., Garaventa, A., Vassal, G., Michon, J., Valteau-Couanet, D., Group, S.E.N., 2017. Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial. Lancet Oncol.

Mutz, C.N., Schwentner, R., Aryee, D.N.T., Bouchard, E.D.J., Mejia, E.M., Hatch, G.M., Kauer, M.O., Katschnig, A.M., Ban, J., Garten, A., Alonso, J., Banerji, V., Kovar, H., 2017 in press. EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells. . Oncotarget.

Nogueira, F., Istel, F., Pereira, L., Tscherner, M., Kuchler, K., 2017. Immunological Identification of Fungal Species. Methods Mol Biol 1508, 339-359.

Radic-Sarikas, B., Tsafou, K.P., Emdal, K.B., Papamarkou, T., Huber, K.V., Mutz, C., Toretsky, J.A., Bennett, K.L., Olsen, J.V., Brunak, S., Kovar, H., Superti-Furga, G., 2017. Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities. Mol Cancer Ther 16, 88-101.

Ranft, A., Seidel, C., Hoffmann, C., Paulussen, M., Warby, A.C., van den Berg, H., Ladenstein, R., Rossig, C., Dirksen, U., Rosenbaum, D., Juergens, H., 2017. Quality of Survivorship in a Rare Disease: Clinicofunctional Outcome and Physical Activity in an Observational Cohort Study of 618 Long-Term Survivors of Ewing Sarcoma. J Clin Oncol, JCO2016706226.

Schmah, J., Fedders, B., Panzer-Grumayer, R., Fischer, S., Zimmermann, M., Dagdan, E., Bens, S., Schewe, D., Moericke, A., Alten, J., Bleckmann, K., Siebert, R., Schrappe, M., Stanulla, M., Cario, G., 2017. Molecular characterization of acute lymphoblastic leukemia with high CRLF2 gene expression in childhood. Pediatr Blood Cancer.

Sheffield, N.C., Pierron, G., Klughammer, J., Datlinger, P., Schonegger, A., Schuster, M., Hadler, J., Surdez, D., Guillemot, D., Lapouble, E., Freneaux, P., Champigneulle, J., Bouvier, R., Walder, D., Ambros, I.M., Hutter, C., Sorz, E., Amaral, A.T., de Alava, E., Schallmoser, K., Strunk, D., Rinner, B., Liegl-Atzwanger, B., Huppertz, B., Leithner, A., de Pinieux, G., Terrier, P., Laurence, V., Michon, J., Ladenstein, R., Holter, W., Windhager, R., Dirksen, U., Ambros, P.F., Delattre, O., Kovar, H., Bock, C., Tomazou, E.M., 2017. DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma. Nat Med.

Smeenk, L., Fischer, M., Jurado, S., Jaritz, M., Azaryan, A., Werner, B., Roth, M., Zuber, J., Stanulla, M., den Boer, M.L., Mullighan, C.G., Strehl, S., Busslinger, M., 2017. Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia. EMBO J.

Sparber-Sauer, M., von Kalle, T., Seitz, G., Dantonello, T., Scheer, M., Munter, M., Fuchs, J., Ladenstein, R., Bielack, S.S., Klingebiel, T., Koscielniak, E., Cooperative Weichteilsarkom, S., 2017. The prognostic value of early radiographic response in children and adolescents with embryonal rhabdomyosarcoma stage IV, metastases confined to the lungs: A report from the Cooperative Weichteilsarkom Studiengruppe (CWS). Pediatr Blood Cancer.

Thannesberger, J., Hellinger, H.-J., Klymiuk, I., Kastner, M.-T., Rieder, F.J.J., Schneider, M., Fister, S., Lion, T., Kosulin, K., Laengle, J., Bergmann, M., Rattei, T., Steininger, C., 2017. Viruses comprise an extensive pool of mobile genetic elements in eukaryote cell cultures and human clinical samples. The FASEB Journal.

Uffmann, M., Rasche, M., Zimmermann, M., von Neuhoff, C., Creutzig, U., Dworzak, M., Scheffers, L., Hasle, H., Zwaan, C.M., Reinhardt, D., Klusmann, J.H., 2017. Therapy reduction in patients with Down Syndrome Myeloid Leukemia: The international ML-DS 2006 trial. Blood.

CCRI Publications 2016

Araki, A., M. Chocholous, J. Gojo, C. Dorfer, T. Czech, H. Heinzl, K. Dieckmann, I.M. Ambros, P.F. Ambros, I. Slavc, and C. Haberler. Chromosome 1q gain and tenascin-C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma. Acta Neuropathol Commun, 2016. 4(1): p. 88.

Berbegall, A.P., E. Villamon, M. Piqueras, I. Tadeo, A. Djos, P.F. Ambros, T. Martinsson, I.M. Ambros, A. Canete, V. Castel, S. Navarro, and R. Noguera. Comparative genetic study of intratumoral heterogenous MYCN amplified neuroblastoma versus aggressive genetic profile neuroblastic tumors. Oncogene, 2016. 35(11): p. 1423-32.

Bileck, A., R.L. Mayer, D. Kreutz, T. Weiss, S. Taschner-Mandl, S.M. Meier, A. Slany, and C. Gerner. Evaluation of inflammation-related signaling events covering phosphorylation and nuclear translocation of proteins based on mass spectrometry data. J Proteomics, 2016. 152: p. 161-171.

Boer, J.M., A. van der Veer, D. Rizopoulos, M. Fiocco, E. Sonneveld, H.A. de Groot-Kruseman, R.P. Kuiper, P. Hoogerbrugge, M. Horstmann, M. Zaliova, C. Palmi, J. Trka, E. Fronkova, M. Emerenciano, M. do Socorro Pombo-de-Oliveira, W. Mlynarski, T. Szczepanski, K. Nebral, A. Attarbaschi, N. Venn, R. Sutton, C.J. Schwab, A. Enshaei, A. Vora, M. Stanulla, M. Schrappe, G. Cazzaniga, V. Conter, M. Zimmermann, A.V. Moorman, R. Pieters, and M.L. den Boer. Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study. Leukemia, 2016. 30(1): p. 32-8.

Bogen, D., C. Brunner, D. Walder, A. Ziegler, R. Abbasi, R.L. Ladenstein, R. Noguera, T. Martinsson, G. Amann, F.H. Schilling, M. Ussowicz, M. Benesch, P.F. Ambros, and I.M. Ambros. The genetic tumor background is an important determinant for heterogeneous MYCN-amplified neuroblastoma. Int J Cancer, 2016. 139(1): p. 153-63.

Boztug, H., T. Hirschmugl, W. Holter, K. Lakatos, L. Kager, D. Trapin, W. Pickl, E. Förster-Waldl, and K. Boztug. NF-kappaB1 Haploinsufficiency Causing Immunodeficiency and EBV-Driven Lymphoproliferation. J Clin Immunol, 2016. 36(6): p. 533-40.

Boztug, H., N. Mühlegger, U. Pötschger, A. Attarbaschi, C. Peters, G. Mann, and M. Dworzak. Antibiotic prophylaxis with teicoplanin on alternate days reduces rate of viridans sepsis and febrile neutropenia in pediatric patients with acute myeloid leukemia. Ann Hematol, 2016.

Brunner, C., B. Brunner-Herglotz, A. Ziegler, C. Frech, G. Amann, R. Ladenstein, I.M. Ambros, and P.F. Ambros. Tumor Touch Imprints as Source for Whole Genome Analysis of Neuroblastoma Tumors. PLoS One, 2016. 11(8): p. e0161369.

Burchill, S.A., K. Beiske, H. Shimada, P.F. Ambros, R. Seeger, G.A. Tytgat, P.R. Brock, M. Haber, J.R. Park, and F. Berthold. Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma; on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group. Cancer, 2016.

Byrgazov, K., R. Kastner, M. Gorna, G. Hoermann, M. Koenig, C.B. Lucini, R. Ulreich, M. Benesch, V. Strenger, H. Lackner, W. Schwinger, P. Sovinz, O.A. Haas, M. van den Heuvel-Eibrink, C.M. Niemeyer, O. Hantschel, P. Valent, G. Superti-Furga, C. Urban, M.N. Dworzak, and T. Lion. NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors. Leukemia, 2016.

Byrgazov, K., C.B. Lucini, B. Berkowitsch, M. Koenig, O.A. Haas, G. Hoermann, P. Valent, and T. Lion. Transposon-mediated generation of BCR-ABL1-expressing transgenic cell lines for unbiased sensitivity testing of tyrosine kinase inhibitors. Oncotarget, 2016.

Chagtai, T., C. Zill, L. Dainese, J. Wegert, S. Savola, S. Popov, W. Mifsud, G. Vujanic, N. Sebire, Y. Le Bouc, P.F. Ambros, L. Kager, M.J. O'Sullivan, A. Blaise, C. Bergeron, L.H. Mengelbier, D. Gisselsson, M. Kool, G.A. Tytgat, M.M. van den Heuvel-Eibrink, N. Graf, H. van Tinteren, A. Coulomb, M. Gessler, R.D. Williams, and K. Pritchard-Jones. Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study. J Clin Oncol, 2016. 34(26): p. 3195-203.

Colomer-Lahiguera, S. and S. Strehl. Complexity of NOTCH1 juxtamembrane insertion mutations in T-cell acute lymphoblastic leukemia. Leuk Lymphoma, 2016. 57(5): p. 1219-22.

Crazzolara, R., G. Kropshofer, O.A. Haas, S. Matthes-Martin, and L. Kager. Reduced-intensity conditioning and stem cell transplantation in infants with Diamond Blackfan anemia. Haematologica, 2017, Epub 2016 Dec. 102(3): p. e73-e75.

Creutzig, U., C. Rössig, M. Dworzak, J. Stary, A. von Stackelberg, W. Wössmann, M. Zimmermann, and D. Reinhardt. Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. Pediatr Blood Cancer, 2016. 63(4): p. 640-5.

Creutzig, U., M. Zimmermann, D. Reinhardt, M. Rasche, C. von Neuhoff, T. Alpermann, M. Dworzak, K. Perglerova, Z. Zemanova, J. Tchinda, J. Bradtke, C. Thiede, and C. Haferlach. Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups. Cancer, 2016.

Czurda, S. and T. Lion. Broad-Spectrum Molecular Detection of Fungal Nucleic Acids by PCR-Based Amplification Techniques. Methods Mol Biol, 2017, Epub 2016 Nov. 1508: p. 257-266.

Czurda, S. and T. Lion. Prerequisites for Control of Contamination in Fungal Diagnosis. Methods Mol Biol, 2017, Epub 2016 Nov. 1508: p. 249-255.

Czurda, S., S. Smelik, S. Preuner-Stix, F. Nogueira, and T. Lion. Occurrence of Fungal DNA Contamination in PCR Reagents: Approaches to Control and Decontamination. J Clin Microbiol, 2016. 54(1): p. 148-52.

Dittrich, C., M. Kosty, S. Jezdic, D. Pyle, R. Berardi, J. Bergh, N. El Saghir, J.P. Lotz, P. Österlund, N. Pavlidis, G. Purkalne, and E.A.G.C.W. Group. ESMO/ASCO recommendations for a Global Curriculum (GC) in medical oncology-edition 2016. Ann Oncol, 2016. 27(8): p. 1378-81.

Dittrich, C., M. Kosty, S. Jezdic, D. Pyle, R. Berardi, J. Bergh, N. El-Saghir, J.P. Lotz, P. Österlund, N. Pavlidis, G. Purkalne, A. Awada, S. Banerjee, S. Bhatia, J. Bogaerts, J. Buckner, F. Cardoso, P. Casali, E. Chu, J.L. Close, B. Coiffier, R. Connolly, S. Coupland, L. De Petris, M. De Santis, E.G. de Vries, D.S. Dizon, J. Duff, L.R. Duska, A. Eniu, M. Ernstoff, E. Felip, M.F. Fey, J. Gilbert, N. Girard, A.W. Glaudemans, P.K. Gopalan, A. Grothey, S.M. Hahn, D. Hanna, C. Herold, J. Herrstedt, K. Homicsko, D.V. Jones, Jr., L. Jost, U. Keilholz, S. Khan, A. Kiss, C.H. Kohne, R. Kunstfeld, H.J. Lenz, S. Lichtman, L. Licitra, T. Lion, S. Litiere, L. Liu, P.J. Loehrer, M.J. Markham, B. Markman, M. Mayerhoefer, J.G. Meran, O. Michielin, E.C. Moser, G. Mountzios, T. Moynihan, T. Nielsen, Y. Ohe, K. Oberg, A. Palumbo, F.A. Peccatori, M. Pfeilstocker, C. Raut, S.C. Remick, M. Robson, P. Rutkowski, R. Salgado, L. Schapira, E. Schernhammer, M. Schlumberger, H.J. Schmoll, L. Schnipper, C. Sessa, C.L. Shapiro, J. Steele, C.N. Sternberg, F. Stiefel, F. Strasser, R. Stupp, R. Sullivan, J. Tabernero, L. Travado, M. Verheij, E. Voest, E. Vokes, J. Von Roenn, J.S. Weber, H. Wildiers, and Y. Yarden. ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016. ESMO Open, 2016. 1(5): p. e000097.

Dmytrus, J., S. Matthes-Martin, H. Pichler, N. Worel, R. Geyeregger, N. Frank, C. Frech, and G. Fritsch. Multi-color immune-phenotyping of CD34 subsets reveals unexpected differences between various stem cell sources. Bone Marrow Transplant, 2016. 51(8): p. 1093-100.

Duregger, K., D. Hayn, M. Nitzlnader, M. Kropf, M. Falgenhauer, R. Ladenstein, and G. Schreier. Electronic Patient Reported Outcomes in Paediatric Oncology - Applying Mobile and Near Field Communication Technology. Stud Health Technol Inform, 2016. 223: p. 281-8.

Ebinger, S., E.Z. Özdemir, C. Ziegenhain, S. Tiedt, C. Castro Alves, M. Grunert, M. Dworzak, C. Lutz, V.A. Turati, T. Enver, H.P. Horny, K. Sotlar, S. Parekh, K. Spiekermann, W. Hiddemann, A. Schepers, B. Polzer, S. Kirsch, M. Hoffmann, B. Knapp, J. Hasenauer, H. Pfeifer, R. Panzer-Grümayer, W. Enard, O. Gires, and I. Jeremias. Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia. Cancer Cell, 2016.

Ebner, H., D. Hayn, M. Falgenhauer, M. Nitzlnader, G. Schleiermacher, R. Haupt, G. Erminio, R. Defferrari, K. Mazzocco, J. Kohler, G.P. Tonini, R. Ladenstein, and G. Schreier. Piloting the European Unified Patient Identity Management (EUPID) Concept to Facilitate Secondary Use of Neuroblastoma Data from Clinical Trials and Biobanking. Stud Health Technol Inform, 2016. 223: p. 31-8.

Eder, J., M. Kammerstatter, F. Erhart, D. Mairhofer-Muri, and F. Trautinger. Illness Perception in Primary Cutaneous T-cell Lymphomas: What Patients Believe About Their Disease. Acta Derm Venereol, 2016. 96(3): p. 381-5.

Eder, J., R. Rogojanu, W. Jerney, F. Erhart, A. Dohnal, M. Kitzwögerer, G. Steiner, J. Moser, and F. Trautinger. Mast Cells Are Abundant in Primary Cutaneous T-Cell Lymphomas: Results from a Computer-Aided Quantitative Immunohistological Study. PLoS One, 2016. 11(11): p. e0163661.

Fritsch, G., N. Frank, J. Dmytrus, C. Frech, H. Pichler, V. Witt, R. Geyeregger, D. Scharner, D. Trbojevic, E. Zipperer, D. Printz, and N. Worel. Relevance of flow cytometric enumeration of post-thaw leucocytes: influence of temperature during cell staining on viable cell recovery. Vox Sang, 2016. 111(2): p. 187-96.

Grausenburger, R., S. Bastelberger, C. Eckert, M. Kauer, M. Stanulla, C. Frech, E. Bauer, D. Stoiber, A. von Stackelberg, A. Attarbaschi, O.A. Haas, and R. Panzer-Grümayer. Genetic alterations in glucocorticoid signaling pathway components are associated with adverse prognosis in children with relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia. Leuk Lymphoma, 2016. 57(5): p. 1163-73.

Grelpois, G., C. Sabbagh, C. Cosse, B. Robert, E. Chapuis-Roux, A. Ntouba, T. Lion, and J.M. Regimbeau. Management of Uncomplicated Acute Appendicitis as Day Case Surgery: Feasibility and a Critical Analysis of Exclusion Criteria and Treatment Failure. J Am Coll Surg, 2016.

Grevener, K., L.M. Haveman, A. Ranft, H. van den Berg, S. Jung, R. Ladenstein, S. Klco-Brosius, H. Juergens, J.H. Merks, and U. Dirksen. Management and Outcome of Ewing Sarcoma of the Head and Neck. Pediatr Blood Cancer, 2016. 63(4): p. 604-10.

Hartz, B., R. Marsh, K. Rao, J.I. Henter, M. Jordan, L. Filipovich, P. Bader, R. Beier, B. Burkhardt, R. Meisel, A. Schulz, B. Winkler, M.H. Albert, J. Greil, G. Karasu, W. Woessmann, S. Corbacioglu, B. Gruhn, W. Holter, J.S. Kühl, P. Lang, M.G. Seidel, P. Veys, A. Löfstedt, S. Ammann, S. Ehl, G. Janka, I. Müller, and K. Lehmberg. The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis. Blood, 2016. 127(25): p. 3281-90.

Hayn, D., M. Falgenhauer, M. Kropf, M. Nitzlnader, S. Welte, H. Ebner, R. Ladenstein, G. Schleiermacher, B. Hero, and G. Schreier. IT Infrastructure for Merging Data from Different Clinical Trials and Across Independent Research Networks. Stud Health Technol Inform, 2016. 228: p. 287-91.

He, T., D. Surdez, J.K. Rantala, S. Haapa-Paananen, J. Ban, M. Kauer, E. Tomazou, V. Fey, J. Alonso, H. Kovar, O. Delattre, and K. Iljin. High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability. Gene, 2017, Epub 2016 Oct 596: p. 137-146.

Heller, G., T. Topakian, C. Altenberger, S. Cerny-Reiterer, S. Herndlhofer, B. Ziegler, P. Datlinger, K. Byrgazov, C. Bock, C. Mannhalter, G. Hörmann, W.R. Sperr, T. Lion, C.C. Zielinski, P. Valent, and S. Zöchbauer-Müller. Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia. Leukemia, 2016. 30(9): p. 1861-8.

Hutter, C. and M. Minkov. Insights into the pathogenesis of Langerhans cell histiocytosis: the development of targeted therapies. Immunotargets Ther, 2016. 5: p. 81-91.

Javaheri, T., Z. Kazemi, J. Pencik, H.T. Pham, M. Kauer, R. Noorizadeh, B. Sax, H. Nivarthi, M. Schlederer, B. Maurer, M. Hofbauer, D.N. Aryee, M. Wiedner, E.M. Tomazou, M. Logan, C. Hartmann, J.P. Tuckermann, L. Kenner, M. Mikula, H. Dolznig, A. Üren, G.H. Richter, F. Grebien, H. Kovar, and R. Moriggl. Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation. Cell Death Dis, 2016. 7(10): p. e2419.

Kager, L., L.J. Bruce, P. Zeitlhofer, J.F. Flatt, T.M. Maia, M.L. Ribeiro, B. Fahrner, G. Fritsch, K. Boztug, and O.A. Haas. Band 3 nullVIENNA , a novel homozygous SLC4A1 p.Ser477X variant causing severe hemolytic anemia, dyserythropoiesis and complete distal renal tubular acidosis. Pediatr Blood Cancer, 2016.

Kager, L., M. Minkov, P. Zeitlhofer, B. Fahrner, F. Ratzinger, K. Boztug, A. Dossenbach-Glaninger, and O.A. Haas. Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia. Pediatr Blood Cancer, 2016. 63(5): p. 914-6.

Kager, L., J. Whelan, U. Dirksen, B. Hassan, J. Anninga, L. Bennister, J.V. Bovee, B. Brennan, J.M. Broto, L. Brugieres, A.M. Cleton-Jansen, C. Copland, A. Dutour, F. Fagioli, S. Ferrari, M. Fiocco, E. Fleuren, N. Gaspar, H. Gelderblom, C. Gerrand, J. Gerss, O. Gonzato, W. van der Graaf, S. Hecker-Nolting, D. Herrero-Martin, S. Klco-Brosius, H. Kovar, R. Ladenstein, C. Lancia, M.C. LeDeley, M.G. McCabe, M. Metzler, O. Myklebost, M. Nathrath, P. Picci, J. Potratz, F. Redini, G.H. Richter, D. Reinke, P. Rutkowski, K. Scotlandi, S. Strauss, D. Thomas, O.M. Tirado, F. Tirode, G. Vassal, and S.S. Bielack. The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report. Clin Sarcoma Res, 2016. 6: p. 3.

Karim-Kos, H.E., M. Hackl, G. Mann, C. Urban, A. Woehrer, I. Slavc, and R. Ladenstein. Trends in incidence, survival and mortality of childhood and adolescent cancer in Austria, 1994-2011. Cancer Epidemiol, 2016. 42: p. 72-81

Kosulin, K., B. Berkowitsch, and T. Lion. Modified pan-adenovirus real-time PCR assay based on genome analysis of seventy HAdV types. J Clin Virol, 2016. 80: p. 60-1.

Kosulin, K., S. Dworzak, A. Lawitschka, S. Matthes-Leodolter, and T. Lion. Comparison of different approaches to quantitative adenovirus detection in stool specimens of hematopoietic stem cell transplant recipients. J Clin Virol, 2016. 85: p. 31-36.

Kosulin, K., E. Geiger, A. Vecsei, W.D. Huber, M. Rauch, E. Brenner, F. Wrba, K. Hammer, A. Innerhofer, U. Pötschger, A. Lawitschka, S. Matthes-Leodolter, G. Fritsch, and T. Lion. Persistence and reactivation of human adenoviruses in the gastrointestinal tract. Clin Microbiol Infect, 2016. 22(4): p. 381 e1-8.

Kovar, H., J. Amatruda, E. Brunet, S. Burdach, F. Cidre-Aranaz, E. de Alava, U. Dirksen, W. van der Ent, P. Grohar, T.G. Grünewald, L. Helman, P. Houghton, K. Iljin, E. Korsching, M. Ladanyi, E. Lawlor, S. Lessnick, J. Ludwig, P. Meltzer, M. Metzler, J. Mora, R. Moriggl, T. Nakamura, T. Papamarkou, B. Radic Sarikas, F. Redini, G.H. Richter, C. Rössig, K. Schadler, B.W. Schäfer, K. Scotlandi, N.C. Sheffield, A. Shelat, E. Snaar-Jagalska, P. Sorensen, K. Stegmaier, E. Stewart, A. Sweet-Cordero, K. Szuhai, O.M. Tirado, F. Tirode, J. Toretsky, K. Tsafou, A. Üren, A. Zinovyev, and O. Delattre. The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease. Oncotarget, 2016. 7(8): p. 8613-24.

Kowalczyk, J.R., M. Samardakiewicz, K. Pritchard-Jones, R. Ladenstein, S. Essiaf, E. Fitzgerald, G. Petrarulo, and G. Vassal. European Survey on Standards of Care in paediatric oncology centres. Eur J Cancer, 2016. 61: p. 11-9.

Kromp, F., I.M. Ambros, T. Weiss, D. Bogen, H. Dodig, M. Berneder, T. Gerber, S. Taschner-Mandl, P.F. Ambros, and A. Hanbury. Machine Learning Framework incorporating Expert Knowledge in Tissue Image Annotation. Proceedings of the International Conference on Pattern Recognition, Cancun, 2016.

Kuttke, M., E. Sahin, J. Pisoni, S. Percig, A. Vogel, D. Kraemmer, L. Hanzl, J.S. Brunner, H. Paar, K. Soukup, A. Halfmann, A.M. Dohnal, C.W. Steiner, S. Blüml, J. Basilio, B. Hochreiter, M. Salzmann, B. Hoesel, G. Lametschwandtner, R. Eferl, J.A. Schmid, and G. Schabbauer. Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition. Oncoimmunology, 2016. 5(7): p. e1164918.

Lewington, V., B. Lambert, U. Poetschger, Z.B. Sever, F. Giammarile, A.J. McEwan, R. Castellani, T. Lynch, B. Shulkin, M. Drobics, A. Staudenherz, and R. Ladenstein. 123I-mIBG scintigraphy in neuroblastoma: development of a SIOPEN semi-quantitative reporting ,method by an international panel. Eur J Nucl Med Mol Imaging, 2016.

Li, J., T. Casteels, T. Frogne, C. Ingvorsen, C. Honore, M. Courtney, K.V. Huber, N. Schmitner, R.A. Kimmel, R.A. Romanov, C. Sturtzel, C.H. Lardeau, J. Klughammer, M. Farlik, S. Sdelci, A. Vieira, F. Avolio, F. Briand, I. Baburin, P. Majek, F.M. Pauler, T. Penz, A. Stukalov, M. Gridling, K. Parapatics, C. Barbieux, E. Berishvili, A. Spittler, J. Colinge, K.L. Bennett, S. Hering, T. Sulpice, C. Bock, M. Distel, T. Harkany, D. Meyer, G. Superti-Furga, P. Collombat, J. Hecksher-Sorensen, and S. Kubicek. Artemisinins Target GABAA Receptor Signaling and Impair alpha Cell Identity. Cell, 2017, Epub 2016 Dec. 168(1-2): p. 86-100.

Lion, T., Human Fungal Pathogen Identification: Methods and Protocols. Methods mol Biol. 2017, Epub 2016 Nov: Springer New York. 453.

Lopes, S.S., M. Distel, C. Linker, R. Fior, R. Monteiro, I.H. Bianco, R. Portugues, U. Strahle, and L. Saude. Report of the 4th European Zebrafish Principal Investigator Meeting. Zebrafish, 2016.

Mann, G. and W. Holter. [Treatment of low-risk pediatric lymphocyte-predominant Hodgkin lymphoma]. Strahlenther Onkol, 2016. 192(11): p. 827-829.

Minas, T.Z., D. Surdez, T. Javaheri, M. Tanaka, M. Howarth, H.J. Kang, J. Han, Z.Y. Han, B. Sax, B.E. Kream, S.H. Hong, H. Celik, F. Tirode, J. Tuckermann, J.A. Toretsky, L. Kenner, H. Kovar, S. Lee, E.A. Sweet-Cordero, T. Nakamura, R. Moriggl, O. Delattre, and A. Üren. Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model. Oncotarget, 2016.

Mutz, C.N., R. Schwentner, M.O. Kauer, A.M. Katschnig, F. Kromp, D.N. Aryee, S. Erhardt, M. Goiny, J. Alonso, D. Fuchs, and H. Kovar. EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway. FEBS Lett, 2016. 590(14): p. 2063-75.

Nitzlnader, M., A. Canete Nieto, A.J. Ribelles, B. Brunmair, R. Ladenstein, and G. Schreier. Interoperability Architecture for a Paediatric Oncology European Reference Network. Stud Health Technol Inform, 2016. 223: p. 39-45.

Perwein, T., S. Strehl, M. König, H. Lackner, R. Panzer-Grümayer, G. Mann, A. Attarbaschi, E.C. Urban, and O.A. Haas. Imatinib-induced long-term remission in a relapsed RCSD1-ABL1-positive acute lymphoblastic leukemia. Haematologica, 2016. 101(8): p. e332-5.

Pichler, H., G. Fritsch, M. König, H. Daxberger, E. Glogova, U. Pötschger, S. Breuer, A. Lawitschka, E.D. Guclu, S. Karlhuber, W. Holter, O.A. Haas, T. Lion, and S. Matthes-Martin. Peripheral blood late mixed chimerism in leucocyte subpopulations following allogeneic stem cell transplantation for childhood malignancies: does it matter? Br J Haematol, 2016. 173(6): p. 905-17.

Posch, C., H. Moslehi, M. Sanlorenzo, G. Green, I. Vujic, R. Panzer-Grümayer, K. Rappersberger, and S. Ortiz-Urda. Pharmacological inhibitors of c-KIT block mutant c-KIT mediated migration of melanocytes and melanoma cells in vitro and in vivo. Oncotarget, 2016.

Posch, C., M. Sanlorenzo, I. Vujic, J.A. Oses-Prieto, B.D. Cholewa, S.T. Kim, J. Ma, K. Lai, M. Zekhtser, R. Esteve-Puig, G. Green, S. Chand, A.L. Burlingame, R. Panzer-Grümayer, K. Rappersberger, and S. Ortiz-Urda. Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2alpha Kinase Levels in NRAS(Q61) Mutant Cells. J Invest Dermatol, 2016. 136(10): p. 2041-8.

Preuner, S., A. Barna, F. Frommlet, S. Czurda, B. Konstantin, M. Alikian, K. Machova Polakova, T. Sacha, J. Richter, T. Lion, and C. Gabriel. Quantitative Analysis of Mutant Subclones in Chronic Myeloid Leukemia: Comparison of Different Methodological Approaches. Int J Mol Sci, 2016. 17(5).

Preuner, S., C. Peters, U. Pötschger, H. Daxberger, G. Fritsch, R. Geyeregger, A. Schrauder, A. von Stackelberg, M. Schrappe, P. Bader, W. Ebell, C. Eckert, P. Lang, K.W. Sykora, J. Schrum, B. Kremens, K. Ehlert, M.H. Albert, R. Meisel, A. Lawitschka, G. Mann, R. Panzer-Grümayer, T. Güngör, W. Holter, B. Strahm, B. Gruhn, A. Schulz, W. Woessmann, and T. Lion. Risk assessment of relapse by lineage-specific monitoring of chimerism in children undergoing allogeneic stem cell transplantation for acute lymphoblastic leukemia. Haematologica, 2016. 101(6): p. 741-6.

Proff, J., C. Walterskirchen, C. Brey, R. Geyeregger, F. Full, A. Ensser, M. Lehner, and W. Holter. Cytomegalovirus-Infected Cells Resist T Cell Mediated Killing in an HLA-Recognition Independent Manner. Front Microbiol, 2016. 7: p. 844.

Radic-Sarikas, B., K.P. Tsafou, K.B. Emdal, T. Papamarkou, K.V.M. Huber, C. Mutz, J.A. Toretsky, K.L. Bennett, J.V. Olsen, S. Brunak, H. Kovar, and G. Superti-Furga. Combinatorial drug screening identifies Ewing sarcoma-specific sensitivities. Molecular Cancer Therapeutics, 2016.

Reismüller, B., M. Steiner, H. Pichler, M. Dworzak, C. Urban, B. Meister, K. Schmitt, U. Pötschger, M. König, G. Mann, O.A. Haas, A. Attarbaschi, and A.L.L.B.F.M.S.G. Austrian. High hyperdiploid acute lymphoblastic leukemia (ALL)-A 25-year population-based survey of the Austrian ALL-BFM (Berlin-Frankfurt-Munster) Study Group. Pediatr Blood Cancer, 2016.

Reiter, M., P. Rota, F. Kleber, M. Diem, S. Groeneveld-Krentz, and M. Dworzak. Clustering of cell populations in flow cytometry data using a combination of Gaussian mixtures. Pattern Recognition, 2016. 60: p. 1029-1040.

Rieder, F.J., C. Gröschel, M.T. Kastner, K. Kosulin, J. Laengle, R. Zadnikar, R. Marculescu, M. Schneider, T. Lion, M. Bergmann, E. Kallay, and C. Steininger. Human cytomegalovirus infection downregulates vitamin-D receptor in mammalian cells. J Steroid Biochem Mol Biol, 2016.

Ruiz-Pinto, S., G. Pita, A. Patino-Garcia, P. Garcia-Miguel, J. Alonso, A. Perez-Martinez, A. Sastre, G. Gomez-Mariano, A. Lissat, K. Scotlandi, M. Serra, R. Ladenstein, E. Lapouble, G. Pierron, U. Kontny, P. Picci, H. Kovar, O. Delattre, and A. Gonzalez-Neira. Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome. Ann Oncol, 2016. 27(9): p. 1788-93.

Scheer, M., T. Dantonello, E. Hallmen, C. Vokuhl, I. Leuschner, M. Sparber-Sauer, B. Kazanowska, F. Niggli, R. Ladenstein, S.S. Bielack, T. Klingebiel, and E. Koscielniak. Primary Metastatic Synovial Sarcoma: Experience of the CWS Study Group. Pediatr Blood Cancer, 2016. 63(7): p. 1198-206.

Schüller, S., A. Attarbaschi, A. Berger, C. Hutter, K. Klebermass-Schrehof, and M. Steiner. Hemophagocytic lymphohistiocytosis triggered by Gaucher disease in a preterm neonate. Pediatric Hematology and Oncology, 2016: p. 1-6.

Schwentner, R., D. Herrero-Martin, M.O. Kauer, C.N. Mutz, A.M. Katschnig, G. Sienski, J. Alonso, D.N. Aryee, and H. Kovar. The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma. Oncotarget, 2016.

Seidel, M.G., K. Boztug, and O.A. Haas. Immune Dysregulation Syndromes (IPEX, CD27 Deficiency, and Others): Always Doomed from the Start? J Clin Immunol, 2016. 36(1): p. 6-7.

Siebert, N., C. Eger, D. Seidel, M. Juttner, M. Zumpe, D. Wegner, S. Kietz, K. Ehlert, G.J. Veal, W. Siegmund, M. Weiss, H. Loibner, R. Ladenstein, and H.N. Lode. Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2. MAbs, 2016. 8(3): p. 604-16.

Sipurzynski, J., B. Fahrner, R. Kerbl, R. Crazzolara, N. Jones, G. Ebetsberger, B. Jauk, V. Strenger, B. Wohlmuther, W. Schwinger, H. Lackner, C. Urban, W. Holter, M. Minkov, L. Kager, M. Benesch, and M.G. Seidel. Management of chronic immune thrombocytopenia in children and adolescents: lessons from an Austrian national cross-sectional study of 81 patients. Semin Hematol, 2016. 53 Suppl 1: p. S43-7.

Smidak, R., J. Aradska, S. Kirchberger, M. Distel, F.J. Sialana, J. Wackerlig, D. Mechtcheriakova, and G. Lubec. A detailed proteomic profiling of plasma membrane from zebrafish brain. Proteomics Clin Appl, 2016.

Stegmaier, S., I. Leuschner, C. Poremba, R. Ladenstein, B. Kazanowska, G. Ljungman, M. Scheer, B. Blank, S. Bielack, T. Klingebiel, and E. Koscielniak. The prognostic impact of SYT-SSX fusion type and histological grade in pediatric patients with synovial sarcoma treated according to the CWS (Cooperative Weichteilsarkom Studie) trials. Pediatr Blood Cancer, 2017, Epub 2016 Sep. 64(1): p. 89-95.

Taschner-Mandl, S., M. Schwarz, J. Blaha, M. Kauer, F. Kromp, N. Frank, F. Rifatbegovic, T. Weiss, R. Ladenstein, M. Hohenegger, I.M. Ambros, and P.F. Ambros. Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence. Oncotarget, 2016. 7(3): p. 3571-86.

Thompson, D., K.T. Vo, W.B. London, M. Fischer, P.F. Ambros, A. Nakagawara, G.M. Brodeur, K.K. Matthay, and S.G. DuBois. Identification of patient subgroups with markedly disparate rates of MYCN amplification in neuroblastoma: A report from the International Neuroblastoma Risk Group project. Cancer, 2016. 122(6): p. 935-45.

Tischer, S., R. Geyeregger, J. Kwoczek, A. Heim, C. Figueiredo, R. Blasczyk, B. Maecker-Kolhoff, and B. Eiz-Vesper. Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection. J Transl Med, 2016. 14(1): p. 286.

Valent, P., B. Groner, U. Schumacher, G. Superti-Furga, M. Busslinger, R. Kralovics, C. Zielinski, J.M. Penninger, D. Kerjaschki, G. Stingl, J.S. Smolen, R. Valenta, H. Lassmann, H. Kovar, U. Jäger, G. Kornek, M. Müller, and F. Sörgel. Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine. J Innate Immun, 2016. 8(2): p. 111-20.

Ventura, S., D.N. Aryee, F. Felicetti, A. De Feo, C. Mancarella, M.C. Manara, P. Picci, M.P. Colombo, H. Kovar, A. Care, and K. Scotlandi. CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-kappaB signaling. Oncogene, 2016. 35(30): p. 3944-54.

Vesely, C., C. Frech, C. Eckert, G. Cario, A. Mecklenbrauker, U. zur Stadt, K. Nebral, F. Kraler, S. Fischer, A. Attarbaschi, M. Schuster, C. Bock, H. Cave, A. von Stackelberg, M. Schrappe, M.A. Horstmann, G. Mann, O.A. Haas, and R. Panzer-Grümayer. Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia. Leukemia, 2016.

Weilner, S., E. Schraml, M. Wieser, P. Messner, K. Schneider, K. Wassermann, L. Micutkova, K. Fortschegger, A.B. Maier, R. Westendorp, H. Resch, S. Wolbank, H. Redl, P. Jansen-Durr, P. Pietschmann, R. Grillari-Voglauer, and J. Grillari. Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells. Aging Cell, 2016. 15(4): p. 744-54.

Weiss, T., S. Taschner-Mandl, A. Bileck, A. Slany, F. Kromp, F. Rifatbegovic, C. Frech, R. Windhager, H. Kitzinger, C.H. Tzou, P.F. Ambros, C. Gerner, and I.M. Ambros. Proteomics and transcriptomics of peripheral nerve tissue and cells unravel new aspects of the human Schwann cell repair phenotype. Glia, 2016. 64(12): p. 2133-2153.

Witt, V., H. Pichler, G. Fritsch, and C. Peters. Multiple small versus few large amount aspirations for bone marrow harvesting in autologous and allogeneic bone marrow transplantation. Transfus Apher Sci, 2016. 55(2): p. 221-224.

Wlodarski, M.W., S. Hirabayashi, V. Pastor, J. Stary, H. Hasle, R. Masetti, M. Dworzak, M. Schmugge, M. van den Heuvel-Eibrink, M. Ussowicz, B. De Moerloose, A. Catala, O.P. Smith, P. Sedlacek, A.C. Lankester, M. Zecca, V. Bordon, S. Matthes-Martin, J. Abrahamsson, J.S. Kühl, K.W. Sykora, M.H. Albert, B. Przychodzien, J.P. Maciejewski, S. Schwarz, G. Göhring, B. Schlegelberger, A. Cseh, P. Noellke, A. Yoshimi, F. Locatelli, I. Baumann, B. Strahm, C.M. Niemeyer, and M.D.S. Ewog. Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents. Blood, 2016. 127(11): p. 1387-97; quiz 1518.

Worel, N., G. Fritsch, H. Agis, A. Bohm, G. Engelich, G.C. Leitner, K. Geissler, K. Gleixner, P. Kalhs, V. Buxhofer-Ausch, F. Keil, G. Kopetzky, V. Mayr, W. Rabitsch, R. Reisner, K. Rosskopf, R. Ruckser, C. Zoghlami, N. Zojer, and H.T. Greinix. Plerixafor as preemptive strategy results in high success rates in autologous stem cell mobilization failure. J Clin Apher, 2016.

Zaliova, M., A.V. Moorman, G. Cazzaniga, M. Stanulla, R.C. Harvey, K.G. Roberts, S.L. Heatley, M.L. Loh, M. Konopleva, I.M. Chen, O. Zimmermannova, C. Schwab, O. Smith, M.J. Mozziconacci, C. Chabannon, M. Kim, J.H. Frederik Falkenburg, A. Norton, K. Marshall, O.A. Haas, J. Starkova, J. Stuchly, S.P. Hunger, D. White, C.G. Mullighan, C.L. Willman, J. Stary, J. Trka, and J. Zuna. Characterization of leukemias with ETV6-ABL1 fusion. Haematologica, 2016. 101(9): p. 1082-93.

Zuna, J., A. Moericke, M. Arens, R. Koehler, R. Panzer-Grümayer, C.R. Bartram, S. Fischer, E. Fronkova, M. Zaliova, A. Schrauder, M. Stanulla, M. Zimmermann, J. Trka, J. Stary, A. Attarbaschi, G. Mann, M. Schrappe, and G. Cario. Implications of delayed bone marrow aspirations at the end of treatment induction for risk stratification and outcome in children with acute lymphoblastic leukaemia. Br J Haematol, 2016. 173(5): p. 742-8.

 

CCRI Publications 2015

Anderl S, König M, Attarbaschi A, Strehl S. PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia. Mol Cytogenet. 2015 Jul 8;8:48. doi: 10.1186/s13039-015-0138-3. eCollection 2015.

Bellutti F, Kauer M, Kneidinger D, Lion T, Klein R. Identification of RISC-Associated Adenoviral MicroRNAs, a Subset of Their Direct Targets, and Global Changes in the Targetome upon Lytic Adenovirus 5 Infection. J Virol. 2015 Feb 1;89(3):1608-27. doi: 10.1128/JVI.02336-14.

Bogen D, Wei JS, Azorsa DO, Ormanoglu P, Buehler E, Guha R, Keller JM, Mathews Griner LA, Ferrer M, Song YK, Liao H, Mendoza A, Gryder BE, Sindri S, He J, Wen X, Zhang S, Shern JF, Yohe ME, Taschner-Mandl S, Shohet JM, Thomas CJ, Martin SE, Ambros PF, Khan J. Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma. Oncotarget. 2015 Nov 3;6(34):35247-62. doi: 10.18632/oncotarget.6208.

Cross NC, White H, Colomer D, Ehrencrona H, Foroni L, Gottardi E, Lange T, Lion T, Polakova KM, Dulucq S, Martinelli G, Leibundgut EO, Pallisgaard N, Barbany G, Sacha T, Talmaci R, Izzo B, Saglio G, Pane F, Müller MC, Hochhaus A, "Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia", Leukemia. 2015 Feb 5. doi: 10.1038/leu.2015.29.

Freimüller C, Stemberger J, Artwohl M, Germeroth L, Witt V, Fischer G, Tischer S, Eiz-Vesper B, Knippertz I, Dörrie J, Schaft N, Lion T, Fritsch G, Geyeregger R. Selection of adenovirus-specific and Epstein-Barr virus-specific T cells with major histocompatibility class I streptamers under Good Manufacturing Practice (GMP)-compliant conditions. Cytotherapy. 2015 Apr 9. pii: S1465-3249(15)00697-0. doi: 10.1016/j.jcyt.2015.03.613. [Epub ahead of print] PMID: 25866178

Grausenburger R, Bastelberger S, Eckert C, Kauer M, Stanulla M, Frech C, Bauer E, Stoiber D, von Stackelberg A, Attarbaschi A, Haas OA, Panzer-Grümayer R. Genetic alterations in glucocorticoid signaling pathway components are associated with adverse prognosis in children with relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia. Leuk Lymphoma. 2015 Sep 1:1-24. [Epub ahead of print]

Heitzeneder S, Zeitlhofer P, Pötschger U, Nowak E, Seidel MG, Hölzl M, Lawitschka A, Förster-Waldl E, Matthes-Martin S, Heja D, Haas OA, Heitger A. Mannan-binding lectin deficiency attenuates acute GvHD in pediatric hematopoietic stem cell transplantation. Bone Marrow Transplant. 2015 Aug;50(8):1127-9. doi: 10.1038/bmt.2015.81. Epub 2015 May 11.

Kosulin K, Zimmerhackl A, Hainfellner JA, Haberler C, Amann G, Lang S, and Lion T. Screening for the Polyomaviruses BKV, JCV and SV40 in Pediatric Malignancies. Int J Cancer Clin Res 2015, 2:019

Kovar H. SLFN11: Achilles' Heel or Troublemaker. Clin Cancer Res. 2015 Sep 15;21(18):4033-4. pii: clincanres.0883.2015. [Epub ahead of print] PMID: 26034126

Malinowska-Ozdowy K, Frech C, Schönegger A, Eckert C, Cazzaniga G, Stanulla M, zur Stadt U, Mecklenbräuker A, Schuster M, Kneidinger D, von Stackelberg A, Locatelli F, Schrappe M, Horstmann MA, Attarbaschi A, Bock C, Mann G, Haas OA, Panzer-Grümayer R. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia. Leukemia. 2015 Aug;29(8):1656-67. doi: 10.1038/leu.2015.107. Epub 2015 Apr 28.

Niemeyer CM, Loh ML, Cseh A, Cooper T, Dvorak CC, Chan R, Xicoy B, Germing U, Kojima S, Manabe A, Dworzak M, De Moerloose B, Starý J, Smith OP, Masetti R, Catala A, Bergstraesser E, Ussowicz M, Fabri O, Baruchel A, Cavé H, Zwaan M, Locatelli F, Hasle H, van den Heuvel-Eibrink MM, Flotho C, Yoshimi A. Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia. Haematologica. 2015 Jan;100(1):17-22. doi: 10.3324/haematol.2014.109892.

Rifatbegovic F, Abbasi MR, Taschner-Mandl S, Kauer M, Weinhäusel A, Handgretinger R, Ambros PF. Enriched Bone Marrow Derived Disseminated Neuroblastoma Cells Can Be a Reliable Source for Gene Expression Studies-A Validation Study. PLoS One. 2015 Sep 11;10(9):e0137995. doi: 10.1371/journal.pone.0137995. eCollection 2015.

Schinnerl D, Fortschegger K, Kauer M, Marchante JR, Kofler R, Den Boer ML, Strehl S. The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia. Blood. 2015 Feb 19;125(8):1282-91. doi: 10.1182/blood-2014-04-570960. Epub 2014 Dec 16.

Raphaela Schwentner, Theodore Papamarkou, Maximilian O. Kauer, Vassilios Stathopoulos, Fan Yang, Sven Bilke, Paul S. Meltzer, Mark Girolami and Heinrich Kovar, EWS-FLI1 employs an E2F switch to drive target gene expression, Nucleic Acids Research, Mar 11;43(5):2780-9. 2015 doi: 10.1093/nar/gkv123

Soukup K, Halfmann A, Le Bras M, Sahin E, Vittori S, Poyer F, Schuh C, Luger R, Niederreiter B, Haider T, Stoiber D, Blüml S, Schabbauer G, Kotlyarov A, Gaestel M, Felzmann T, Dohnal AM. The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis. J Immunol. 2015 Jul 15;195(2):541-52. doi: 10.4049/jimmunol.1401663. Epub 2015 Jun 15. PMID: 26078274.

Tamamyan G, Dominkus M, Lang S, Diakos C, Mittheisz E, Horcher E, Holter W, Zoubek A, Bielack S, Kager L. Multiple relapses in high-grade osteosarcoma: When to stop aggressive therapy? Pediatr Blood Cancer. 2015 Mar;62(3):529-30. doi: 10.1002/pbc.25360. Epub 2014 Dec 8.

Sabine Taschner-Mandl, Magdalena Schwarz, Johanna Blaha, Maximilian Kauer, Florian Kromp, Nelli Frank, Fikret Rifatbegovic, Tamara Weiss, Ruth Ladenstein, Martin Hohenegger, Inge M. Ambros, Peter F. Ambros. Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence.  DOI: 10.18632/oncotarget.6527 Dec. 2015

Tomazou EM, Nathan C. Sheffield, Christian Schmidl, Michael Schuster, Andreas Schönegger, Paul Datlinger, Stefan Kubicek, Christoph Bock, Heinrich Kovar (2015). Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. Cell Reports, 2015 Feb 24;10(7):1082-95.10:1-14. (Feb 27; online publication Feb 19)

Woutsas S, Aytekin C, Salzer E, Conde CD, Apaydin S, Pichler H, Memaran-Dadgar N, Hosnut FO, Förster-Waldl E, Matthes S, Huber WD, Lion T, Holter W, Bilic I, Boztug K. Hypomorphic mutation in TTC7A causes combined immunodeficiency with mild structural intestinal defects. Blood. 2015 Mar 5;125(10):1674-6. doi: 10.1182/blood-2014-08-595397.

CCRI Publications 2014

A. M. Aalbers, M. M. van den Heuvel-Eibrink, I. Baumann, H. B. Beverloo, G. J. Driessen, M. Dworzak, A. Fischer, G. Gohring, H. Hasle, F. Locatelli, B. De Moerloose, P. Noellke, M. Schmugge, J. Stary, A. Yoshimi, M. Zecca, C. M. Zwaan, J. J. van Dongen, R. Pieters, C. M. Niemeyer, V. H. van der Velden, and A. W. Langerak, 'T-Cell Receptor Vbeta Skewing Frequently Occurs in Refractory Cytopenia of Childhood and Is Associated with an Expansion of Effector Cytotoxic T Cells: A Prospective Study by Ewog-Mds', Blood Cancer J, 4 (2014), e209.

A. M. Aalbers, V. H. van der Velden, A. Yoshimi, A. Fischer, P. Noellke, C. M. Zwaan, I. Baumann, H. B. Beverloo, M. Dworzak, H. Hasle, F. Locatelli, B. De Moerloose, G. Gohring, M. Schmugge, J. Stary, M. Zecca, A. W. Langerak, J. J. van Dongen, R. Pieters, C. M. Niemeyer, and M. M. van den Heuvel-Eibrink, 'The Clinical Relevance of Minor Paroxysmal Nocturnal Hemoglobinuria Clones in Refractory Cytopenia of Childhood: A Prospective Study by Ewog-Mds', Leukemia, 28 (2014), 189-92.

M.R. Abbasi, F. Rifatbegovic, C. Brunner, R. Ladenstein, I.M. Ambros, P.F. Ambros, 'Bone marrows from neuroblastoma patients: an excellent source for tumor genome analyses', Molecular Oncology Mol Oncol. 2014 Oct 28. pii: S1574-7891(14)00249-X. doi: 10.1016/j.molonc.2014.10.010. [Epub ahead of print] (2014) 1e1 0.

A. Agaimy, K. D. Stachel, J. Jungert, T. Radkow, R. Carbon, M. Metzler, and W. Holter, 'Malignant Epithelioid Peripheral Nerve Sheath Tumor with Prominent Reticular/Microcystic Pattern in a Child: A Low-Grade Neoplasm with 18-Years Follow-Up', Appl Immunohistochem Mol Morphol, 22 (2014), 627-33.

S.M. Ahmadi, M.A. Hölzl, E. Mayer, T. Wekerle, A. Heitger, 'CTLA4-Ig Preserves Thymus-Derived T Regulatory Cells', Transplantation. 2014 Sep 29. [Epub ahead of print]  PMID: 25269023.

I. M. Ambros, C. Brunner, R. Abbasi, C. Frech, and P. F. Ambros, 'Ultra-High Density Snparray in Neuroblastoma Molecular Diagnostics', Front Oncol, 4 (2014), 202.

A. Attarbaschi, R. Panzer-Grumayer, G. Mann, A. Moricke, M. Konig, A. Mecklenbrauker, A. Teigler-Schlegel, J. Bradtke, J. Harbott, G. Gohring, M. Stanulla, M. Schrappe, M. Zimmermann, O. A. Haas, Austrian on behalf of the, and A. L. L. B. F. M. Study Group German, 'Minimal Residual Disease-Based Treatment Is Adequate for Relapse-Prone Childhood Acute Lymphoblastic Leukemia with an Intrachromosomal Amplification of Chromosome 21: The Experience of the All-Bfm 2000 Trial', Klin Padiatr, 226 (2014), 338-43.

J. Ban, D. Aryee, A. Fourtouna, W. van der Ent, M. Kauer, S. Niedan, I. Machado, C. Rodriguez-Galindo, O.M. Tirado, R. Schwentner, P. Picci, A.M. Flanagan, V. Berg, S.J. Strauss, K. Scotlandi, E.R. Lawlor, E. Snaar-Jagalska, A. Llombart-Bosch, H. Kovar, 'Suppression of deacetylase SIRT1 mediates tumor suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma', Cancer Research, (2014) published OnlineFirst October 3; doi: 10.1158/0008-5472.CAN-14-1736

S. A. Ban, E. Salzer, M. M. Eibl, A. Linder, C. B. Geier, E. Santos-Valente, W. Garncarz, T. Lion, R. Ott, C. Seelbach, K. Boztug, and H. M. Wolf, 'Combined Immunodeficiency Evolving into Predominant Cd4+ Lymphopenia Caused by Somatic Chimerism in Jak3', J Clin Immunol (2014).

H. Boztug, N. Mühlegger, E. Glogova, G. Mann, C. Urban, B. Meister, K. Schmitt, N. Jones, A. Attarbaschi, O. Haas, S. Strehl, T. Lion, U. Pötschger, F.-M. Fink, H. Gadner, M. Dworzak, 'Development of treatment and clinical results in childhood AML in Austria (1993–2013)', Magazine of European Oncology, February 2014, Volume 7, Issue 1, pp 63-74.

J. Buchroithner, J. Pichler, C. Marosi, G. Widhalm, M. Seiz-Rosenhagen, M. Novosielski, S. Oberndorfer, R. Ruckser, K. Rossler, A. Azizi, G. von Campe, K. Bordihn, and T. Felzmann, 'Vascular Endothelia Growth Factor Targeted Therapy May Improve the Effect of Dendritic Cell-Based Cancer Immune Therapy', Int J Clin Pharmacol Ther, 52 (2014), 76-7.

T. D. Buitenkamp, S. Izraeli, M. Zimmermann, E. Forestier, N. A. Heerema, M. M. van den Heuvel-Eibrink, R. Pieters, C. M. Korbijn, L. B. Silverman, K. Schmiegelow, D. C. Liang, K. Horibe, M. Arico, A. Biondi, G. Basso, K. R. Rabin, M. Schrappe, G. Cario, G. Mann, M. Morak, R. Panzer-Grumayer, V. Mondelaers, T. Lammens, H. Cave, B. Stark, I. Ganmore, A. V. Moorman, A. Vora, S. P. Hunger, C. H. Pui, C. G. Mullighan, A. Manabe, G. Escherich, J. R. Kowalczyk, J. A. Whitlock, and C. M. Zwaan, 'Acute Lymphoblastic Leukemia in Children with Down Syndrome: A Retrospective Analysis from the Ponte Di Legno Study Group', Blood, 123 (2014), 70-7.

E. A. Coenen, C. M. Zwaan, J. Stary, A. Baruchel, V. de Haas, R. W. Stam, D. Reinhardt, G. J. Kaspers, S. T. Arentsen-Peters, C. Meyer, R. Marschalek, L. L. Nigro, M. Dworzak, R. Pieters, and M. M. van den Heuvel-Eibrink, 'Unique Bhlhb3 Overexpression in Pediatric Acute Myeloid Leukemia with T(6;11)(Q27;Q23)', Leukemia, 28 (2014), 1564-8.

U. Creutzig, M. Zimmermann, M. N. Dworzak, B. Gibson, R. Tamminga, J. Abrahamsson, S. Y. Ha, H. Hasle, A. Maschan, Y. Bertrand, G. Leverger, C. von Neuhoff, B. Razzouk, C. Rizzari, P. Smisek, O. P. Smith, B. Stark, D. Reinhardt, and G. L. Kaspers, 'The Prognostic Significance of Early Treatment Response in Pediatric Relapsed Acute Myeloid Leukemia: Results of the International Study Relapsed Aml 2001/01', Haematologica, 99 (2014), 1472-8.

T. M. Dantonello, M. Stark, B. Timmermann, J. Fuchs, B. Selle, C. Linderkamp, R. Handgretinger, R. Hagen, S. Feuchtgruber, S. Kube, D. Kosztyla, B. Kazanowska, R. Ladenstein, F. Niggli, G. Ljungman, S. S. Bielack, T. Klingebiel, E. Koscielniak, and Studiengruppe Cooperative Weichteilsarkom, 'Tumour Volume Reduction after Neoadjuvant Chemotherapy Impacts Outcome in Localised Embryonal Rhabdomyosarcoma', Pediatr Blood Cancer, 62 (2015), 16-23.

R. Defferrari, K. Mazzocco, I. M. Ambros, P. F. Ambros, C. Bedwell, K. Beiske, J. Benard, A. P. Berbegall, N. Bown, V. Combaret, J. Couturier, G. Erminio, C. Gambini, A. Garaventa, N. Gross, R. Haupt, J. Kohler, M. Jeison, J. Lunec, B. Marques, T. Martinsson, R. Noguera, S. Parodi, G. Schleiermacher, D. A. Tweddle, A. Valent, N. Van Roy, A. Vicha, E. Villamon, and G. P. Tonini, 'Influence of Segmental Chromosome Abnormalities on Survival in Children over the Age of 12 Months with Unresectable Localised Peripheral Neuroblastic Tumours without Mycn Amplification', Br J Cancer (2014).

D. Denk, J. Bradtke, M. Konig, and S. Strehl, 'Pax5 Fusion Genes in T(7;9)(q11.2;p13) Leukemia: A Case Report and Review of the Literature', Mol Cytogenet, 7 (2014), 13.

C. Diakos, Y. Xiao, S. Zheng, L. Kager, M. Dworzak, and J. L. Wiemels, 'Direct and Indirect Targets of the E2a-Pbx1 Leukemia-Specific Fusion Protein', PLoS One, 9 (2014), e87602.

J. Dörrie, C. Krug, C. Hofmann, I. Müller, V. Wellner, I. Knippertz, S. Schierer, S. Thomas, E. Zipperer, D. Printz, G. Fritsch, G. Schuler, N. Schaft, R. Geyeregger, 'Human Adenovirus-Specific γ/δ and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation', PLOS One (2014) Published: October 07, 2014DOI: 10.1371/journal.pone.0109944

M.N. Dworzak, 'Cure and care for children and adolescents with acute myeloid leukemia in Middle and Eastern European countries: part II', Magazine of European Medical Oncology DOI 10.1007/s12254-014-0134-z.

M. Floderer, M. Prchal-Murphy, C. Vizzardelli, 'Dendritic Cell-Secreted Lipocalin2 Induces CD8+ T-Cell Apoptosis, Contributes to T-Cell Priming and Leads to a TH1 Phenotype', PLoS One. 2014 Jul 10;9(7).

K. Fortschegger, S. Anderl, D. Denk, and S. Strehl, 'Functional Heterogeneity of Pax5 Chimeras Reveals Insight for Leukemia Development', Mol Cancer Res, 12 (2014), 595-606.

R. Geyeregger, C. Freimuller, J. Stemberger, M. Artwohl, V. Witt, T. Lion, G. Fischer, A. Lawitschka, J. Ritter, M. Hummel, W. Holter, G. Fritsch, and S. Matthes-Martin, 'First-in-Man Clinical Results with Good Manufacturing Practice (Gmp)-Compliant Polypeptide-Expanded Adenovirus-Specific T Cells after Haploidentical Hematopoietic Stem Cell Transplantation', J Immunother, 37 (2014), 245-9.

R. Geyeregger, C. Freimuller, J. Stemberger, G. Fischer, V. Witt, and G. Fritsch, 'Human Adv-Specific T Cells: Persisting in Vitro Functionality Despite Lethal Irradiation', Bone Marrow Transplant, 49 (2014), 934-41.

L. J. Hajingabo, S. Daakour, M. Martin, R. Grausenburger, R. Panzer-Grumayer, F. Dequiedt, N. Simonis, and J. C. Twizere, 'Predicting Interactome Network Perturbations in Human Cancer: Application to Gene Fusions in Acute Lymphoblastic Leukemia', Mol Biol Cell, 25 (2014), 3973

C. J. Harrison, A. V. Moorman, C. Schwab, A. J. Carroll, E. A. Raetz, M. Devidas, S. Strehl, K. Nebral, J. Harbott, A. Teigler-Schlegel, M. Zimmerman, N. Dastuge, A. Baruchel, J. Soulier, M. F. Auclerc, A. Attarbaschi, G. Mann, B. Stark, G. Cazzaniga, L. Chilton, P. Vandenberghe, E. Forestier, I. Haltrich, S. C. Raimondi, M. Parihar, J. P. Bourquin, J. Tchinda, C. Haferlach, A. Vora, S. P. Hunger, N. A. Heerema, O. A. Haas, and Leukemia Ponte di Legno International Workshop in Childhood Acute Lymphoblastic, 'An International Study of Intrachromosomal Amplification of Chromosome 21 (Iamp21): Cytogenetic Characterization and Outcome', Leukemia, 28 (2014), 1015-21.

O. Hrusak, G. Basso, R. Ratei, G. Gaipa, D. Luria, E. Mejstrikova, L. Karawajew, B. Buldini, E. Rozenthal, J. P. Bourquin, T. Kalina, M. Sartor, M. N. Dworzak, and Aieop-Bfm Flow Network, 'Flow Diagnostics Essential Code: A Simple and Brief Format for the Summary of Leukemia Phenotyping', Cytometry B Clin Cytom, 86 (2014), 288-91.

M. Ilander, P. Koskenvesa, S. Hernesniemi, T. Lion, K. Porkka, and S. Mustjoki, 'Induction of Sustained Deep Molecular Response in a Patient with Chronic-Phase T315i-Mutated Chronic Myeloid Leukemia with Interferon-Alpha Monotherapy', Leuk Lymphoma, 55 (2014), 934-7.

U. Kaindl, M. Morak, C. Portsmouth, A. Mecklenbrauker, M. Kauer, M. Zeginigg, A. Attarbaschi, O. A. Haas, and R. Panzer-Grumayer, 'Blocking Etv6/Runx1-Induced Mdm2 Overexpression by Nutlin-3 Reactivates P53 Signaling in Childhood Leukemia', Leukemia, 28 (2014), 600-8.

R. Kastner, A. Zopf, S. Preuner, J. Proll, N. Niklas, P. Foskett, P. Valent, T. Lion, and C. Gabriel, 'Rapid Identification of Compound Mutations in Patients with Philadelphia-Positive Leukaemias by Long-Range Next Generation Sequencing', Eur J Cancer, 50 (2014), 793-800.

M. Koenighofer, T. Lion, A. Bodenteich, E. Prieschl-Grassauer, A. Grassauer, H. Unger, C. A. Mueller, and T. Fazekas, 'Carrageenan Nasal Spray in Virus Confirmed Common Cold: Individual Patient Data Analysis of Two Randomized Controlled Trials', Multidiscip Respir Med, 9 (2014), 57.

K. Kosulin, M. Rauch, P. F. Ambros, U. Potschger, A. Chott, U. Jager, J. Drach, A. Nader, and T. Lion, 'Screening for Adenoviruses in Haematological Neoplasia: High Prevalence in Mantle Cell Lymphoma', Eur J Cancer, 50 (2014), 622-7.H.

Kovar, 'Blocking the Road, Stopping the Engine or Killing the Driver? Advances in Targeting Ews/Fli-1 Fusion in Ewing Sarcoma as Novel Therapy', Expert Opin Ther Targets (2014), 1-14.

J. R. Kowalczyk, M. Samardakiewicz, E. Fitzgerald, S. Essiaf, R. Ladenstein, G. Vassal, A. Kienesberger, and K. Pritchard-Jones, 'Towards Reducing Inequalities: European Standards of Care for Children with Cancer', Eur J Cancer, 50 (2014), 481-5.

M. C. Le Deley, M. Paulussen, I. Lewis, B. Brennan, A. Ranft, J. Whelan, G. Le Teuff, J. Michon, R. Ladenstein, P. Marec-Berard, H. van den Berg, L. Hjorth, K. Wheatley, I. Judson, H. Juergens, A. Craft, O. Oberlin, and U. Dirksen, 'Cyclophosphamide Compared with Ifosfamide in Consolidation Treatment of Standard-Risk Ewing Sarcoma: Results of the Randomized Noninferiority Euro-Ewing99-R1 Trial', J Clin Oncol, 32 (2014), 2440-8.

T. Lion, 'Adenovirus Infections in Immunocompetent and Immunocompromised Patients', Clin Microbiol Rev, 27 (2014), 441-62.

H. J. Meany, W. B. London, P. F. Ambros, K. K. Matthay, T. Monclair, T. Simon, A. Garaventa, F. Berthold, A. Nakagawara, S. L. Cohn, A. D. Pearson, and J. R. Park, 'Significance of Clinical and Biologic Features in Stage 3 Neuroblastoma: A Report from the International Neuroblastoma Risk Group Project', Pediatr Blood Cancer (2014).

B. Meissner, T. Bartram, C. Eckert, J. Trka, R. Panzer-Grumayer, I. Hermanova, E. Ellinghaus, A. Franke, A. Moricke, A. Schrauder, A. Teigler-Schlegel, P. Dorge, A. von Stackelberg, G. Basso, C. R. Bartram, R. Kirschner-Schwabe, B. Bornhauser, J. P. Bourquin, G. Cazzaniga, J. Hauer, A. Attarbaschi, S. Izraeli, M. Zaliova, G. Cario, M. Zimmermann, S. Avigad, M. Sokalska-Duhme, M. Metzler, M. Schrappe, R. Koehler, G. Te Kronnie, and M. Stanulla, 'Frequent and Sex-Biased Deletion of Slx4ip by Illegitimate V(D)J-Mediated Recombination in Childhood Acute Lymphoblastic Leukemia', Hum Mol Genet, 23 (2014), 590-601.

D. A. Morgenstern, W. B. London, D. Stephens, S. L. Volchenboum, B. Hero, A. Di Cataldo, A. Nakagawara, H. Shimada, P. F. Ambros, K. K. Matthay, S. L. Cohn, A. D. Pearson, and M. S. Irwin, 'Metastatic Neuroblastoma Confined to Distant Lymph Nodes (Stage 4n) Predicts Outcome in Patients with Stage 4 Disease: A Study from the International Neuroblastoma Risk Group Database', J Clin Oncol, 32 (2014), 1228-35.

Y. P. Mosse, R. J. Deyell, F. Berthold, A. Nagakawara, P. F. Ambros, T. Monclair, S. L. Cohn, A. D. Pearson, W. B. London, and K. K. Matthay, 'Neuroblastoma in Older Children, Adolescents and Young Adults: A Report from the International Neuroblastoma Risk Group Project', Pediatr Blood Cancer, 61 (2014), 627-35.

S. Niedan, M. Kauer, D. N. Aryee, R. Kofler, R. Schwentner, A. Meier, U. Potschger, U. Kontny, and H. Kovar, 'Suppression of Foxo1 Is Responsible for a Growth Regulatory Repressive Transcriptional Sub-Signature of Ews-Fli1 in Ewing Sarcoma', Oncogene, 33 (2014), 3927-38.

H. Pichler, V. Witt, E. Winter, H. Boztug, E. Glogova, U. Potschger, S. Matthes-Martin, and G. Fritsch, 'No Impact of Total or Myeloid Cd34+ Cell Numbers on Neutrophil Engraftment and Transplantation-Related Mortality after Allogeneic Pediatric Bone Marrow Transplantation', Biol Blood Marrow Transplant, 20 (2014), 676-83.

A. R. Poetsch, D. B. Lipka, T. Witte, R. Claus, P. Nollke, M. Zucknick, C. Olk-Batz, S. Fluhr, M. Dworzak, B. De Moerloose, J. Stary, M. Zecca, H. Hasle, M. Schmugge, M. M. van den Heuvel-Eibrink, F. Locatelli, C. M. Niemeyer, C. Flotho, and C. Plass, 'Rasa4 Undergoes DNA Hypermethylation in Resistant Juvenile Myelomonocytic Leukemia', Epigenetics, 9 (2014), 1252-60.

S. Preuner, M. Danzer, J. Proll, U. Potschger, A. Lawitschka, C. Gabriel, and T. Lion, 'High-Quality DNA from Fingernails for Genetic Analysis', J Mol Diagn, 16 (2014), 459-66.

S. Preuner, and T. Lion, 'Post-Transplant Monitoring of Chimerism by Lineage-Specific Analysis', Methods Mol Biol, 1109 (2014), 271-91.

M. Reiter, J. Hoffmann, F. Kleber, A. Schumich, G. Peter, F. Kromp, M. Kampel, M. Dworzak, 'Towards automation of flow cytometric analysis for quality-assured follow-up assessment to guide curative therapy for acute lymphoblastic leukaemia in children', Magazine of European Medical Oncology, Epub ahead of print DOI 10.1007/s12254-014-0172-6.

Reiter M., Kromp F., Ambros P.F., 'Semi-Automated Segmentation of Neuroblastoma Nuclei Using the Gradient Energy Tensor: A User Driven Approach', 2014 The 7th International Conference on Machine Vision ICMV 2014, V092 (2014).

I. Sadovnik, E. Lierman, B. Peter, H. Herrmann, V. Suppan, G. Stefanzl, O. Haas, T. Lion, W. Pickl, J. Cools, P. Vandenberghe, and P. Valent, 'Identification of Ponatinib as a Potent Inhibitor of Growth, Migration, and Activation of Neoplastic Eosinophils Carrying Fip1l1-Pdgfra', Exp Hematol, 42 (2014), 282-93 e4.

E. Sahin, S. Haubenwallner, M. Kuttke, I. Kollmann, A. Halfmann, A. B. Dohnal, L. Chen, P. Cheng, B. Hoesel, E. Einwallner, J. Brunner, J. B. Kral, W. C. Schrottmaier, K. Thell, V. Saferding, S. Bluml, and G. Schabbauer, 'Macrophage Pten Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses', J Immunol, 193 (2014), 1717-27.

E. Sahin, S. Haubenwallner, M. Kuttke, I. Kollmann, A. Halfmann, A. M. Dohnal, L. Chen, P. Cheng, B. Hoesel, E. Einwallner, J. Brunner, J. B. Kral, W. C. Schrottmaier, K. Thell, V. Saferding, S. Bluml, and G. Schabbauer, 'Correction: Macrophage Pten Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses', J Immunol, 193 (2014), 5350.

L. Slamova, J. Starkova, E. Fronkova, M. Zaliova, L. Reznickova, F. W. van Delft, E. Vodickova, J. Volejnikova, Z. Zemanova, K. Polgarova, G. Cario, M. Figueroa, T. Kalina, K. Fiser, J. P. Bourquin, B. Bornhauser, M. Dworzak, J. Zuna, J. Trka, J. Stary, O. Hrusak, and E. Mejstrikova, 'Cd2-Positive B-Cell Precursor Acute Lymphoblastic Leukemia with an Early Switch to the Monocytic Lineage', Leukemia, 28 (2014), 609-20.

Svoboda LK, Harris A, Bailey NJ, Schwentner R, Tomazou E, von Levetzow C, Magnuson B, Ljungman M, Kovar H, Lawlor ER. Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs. Epigenetics. 2014 Dec 2;9(12):1613-25. doi: 10.4161/15592294.2014.988048.

P. Valent, I. Sadovnik, Z. Racil, H. Herrmann, K. Blatt, S. Cerny-Reiterer, G. Eisenwort, T. Lion, T. Holyoake, and J. Mayer, 'Dppiv (Cd26) as a Novel Stem Cell Marker in Ph+ Chronic Myeloid Leukaemia', Eur J Clin Invest, 44 (2014), 1239-45.

G. Vassal, E. Fitzgerald, M. Schrappe, F. Arnold, J. Kowalczyk, D. Walker, L. Hjorth, R. Riccardi, A. Kienesberger, K. P. Jones, M. G. Valsecchi, D. Janic, H. Hasle, P. Kearns, G. Petrarulo, F. Florindi, S. Essiaf, and R. Ladenstein, 'Challenges for Children and Adolescents with Cancer in Europe: The Siop-Europe Agenda', Pediatr Blood Cancer, 61 (2014), 1551-7.

E. Vecsei, S. Steinwendner, H. Kogler, A. Innerhofer, K. Hammer, O. A. Haas, G. Amann, A. Chott, H. Vogelsang, R. Schoenlechner, W. Huf, and A. Vecsei, 'Follow-up of Pediatric Celiac Disease: Value of Antibodies in Predicting Mucosal Healing, a Prospective Cohort Study', BMC Gastroenterol, 14 (2014), 28.

V. F. Viprey, W. M. Gregory, M. V. Corrias, A. Tchirkov, K. Swerts, A. Vicha, S. Dallorso, P. Brock, R. Luksch, D. Valteau-Couanet, V. Papadakis, G. Laureys, A. D. Pearson, R. Ladenstein, and S. A. Burchill, 'Neuroblastoma Mrnas Predict Outcome in Children with Stage 4 Neuroblastoma: A European Hr-Nbl1/Siopen Study', J Clin Oncol, 32 (2014), 1074-83.

K. T. Vo, K. K. Matthay, J. Neuhaus, W. B. London, B. Hero, P. F. Ambros, A. Nakagawara, D. Miniati, K. Wheeler, A. D. Pearson, S. L. Cohn, and S. G. DuBois, 'Clinical, Biologic, and Prognostic Differences on the Basis of Primary Tumor Site in Neuroblastoma: A Report from the International Neuroblastoma Risk Group Project', J Clin Oncol. 2014 Oct 1;32(28):3169-76. doi: 10.1200/JCO.2014.56.1621. Epub 2014 Aug 25.

H. White, L. Deprez, P. Corbisier, V. Hall, F. Lin, S. Mazoua, S. Trapmann, A. Aggerholm, H. Andrikovics, S. Akiki, G. Barbany, N. Boeckx, A. Bench, M. Catherwood, J. M. Cayuela, S. Chudleigh, T. Clench, D. Colomer, F. Daraio, S. Dulucq, J. Farrugia, L. Fletcher, L. Foroni, R. Ganderton, G. Gerrard, E. Gineikiene, S. Hayette, H. El Housni, B. Izzo, M. Jansson, P. Johnels, T. Jurcek, V. Kairisto, A. Kizilors, D. W. Kim, T. Lange, T. Lion, K. M. Polakova, G. Martinelli, S. McCarron, P. A. Merle, B. Milner, G. Mitterbauer-Hohendanner, M. Nagar, G. Nickless, J. Nomdedeu, D. A. Nymoen, E. O. Leibundgut, U. Ozbek, T. Pajic, H. Pfeifer, C. Preudhomme, K. Raudsepp, G. Romeo, T. Sacha, R. Talmaci, T. Touloumenidou, V. H. Van der Velden, P. Waits, L. Wang, E. Wilkinson, G. Wilson, D. Wren, R. Zadro, J. Ziermann, K. Zoi, M. C. Muller, A. Hochhaus, H. Schimmel, N. C. Cross, and H. Emons, 'A Certified Plasmid Reference Material for the Standardisation of Bcr-Abl1 Mrna Quantification by Real-Time Quantitative Pcr', Leukemia (2014).

J. J. Yang, T. S. Park, S. T. Lee, J. Y. Seo, S. H. Oh, E. H. Cho, S. Strehl, N. Muhlegger, M. N. Dworzak, J. Zuna, D. Pospisilova, C. Meyer, R. Marschalek, H. J. Kim, and S. H. Kim, 'Molecular Characterization and Clinical Impact of T(11;15)(Q23;Q14-15) Mll-Casc5 Rearrangement', Haematologica, 99 (2014), e11-3.

A. Yoshimi, M. M. van den Heuvel-Eibrink, I. Baumann, S. Schwarz, I. Simonitsch-Klupp, P. de Paepe, V. Campr, G. B. Kerndrup, M. O'Sullivan, R. Devito, R. Leguit, M. Hernandez, M. Dworzak, B. de Moerloose, J. Stary, H. Hasle, O. P. Smith, M. Zecca, A. Catala, M. Schmugge, F. Locatelli, M. Fuhrer, A. Fischer, A. Guderle, P. Nollke, B. Strahm, and C. M. Niemeyer, 'Comparison of Horse and Rabbit Antithymocyte Globulin in Immunosuppressive Therapy for Refractory Cytopenia of Childhood', Haematologica, 99 (2014), 656-63.

CCRI Publications 2013

A. M. Aalbers, M. M. van den Heuvel-Eibrink, V. de Haas, J. G. Te Marvelde, A. X. de Jong, M. van der Burg, M. Dworzak, H. Hasle, F. Locatelli, B. De Moerloose, M. Schmugge, J. Stary, M. Zecca, C. M. Zwaan, A. A. van de Loosdrecht, J. J. van Dongen, C. M. Niemeyer, and V. H. van der Velden, 'Applicability of a Reproducible Flow Cytometry Scoring System in the Diagnosis of Refractory Cytopenia of Childhood', Leukemia, 27 (2013), 1923-5.

D. N. Aryee, S. Niedan, J. Ban, R. Schwentner, K. Muehlbacher, M. Kauer, R. Kofler, and H. Kovar, 'Variability in Functional P53 Reactivation by Prima-1(Met)/Apr-246 in Ewing Sarcoma', Br J Cancer, 109 (2013), 2696-704.

R. Beier, M. H. Albert, P. Bader, A. Borkhardt, U. Creutzig, M. Eyrich, K. Ehlert, B. Gruhn, J. Greil, R. Handgretinger, W. Holter, T. Klingebiel, B. Kremens, P. Lang, C. Mauz-Korholz, R. Meisel, I. Muller, C. Peters, D. Reinhardt, P. Sedlacek, A. Schulz, F. R. Schuster, A. Schrauder, B. Strahm, K. W. Sykora, W. Wossmann, M. Zimmermann, and M. G. Sauer, 'Allo-Sct Using Bu, Cy and Melphalan for Children with Aml in Second Cr', Bone Marrow Transplant, 48 (2013), 651-6.

R. Beier, A. Schulz, M. Honig, M. Eyrich, P. G. Schlegel, W. Holter, K. D. Stachel, K. Ehlert, J. Greil, W. Nurnberger, W. Wossmann, P. Bader, C. Urban, I. Muller, M. Suttorp, M. Sauer, B. Gruhn, R. Meisel, M. Zimmermann, and K. W. Sykora, 'Long-Term Follow-up of Children Conditioned with Treosulfan: German and Austrian Experience', Bone Marrow Transplant, 48 (2013), 491-501.

S. Bilke, R. Schwentner, F. Yang, M. Kauer, G. Jug, R. L. Walker, S. Davis, Y. J. Zhu, M. Pineda, P. S. Meltzer, and H. Kovar, 'Oncogenic Ets Fusions Deregulate E2f3 Target Genes in Ewing Sarcoma and Prostate Cancer', Genome Res, 23 (2013), 1797-809.

H. Boztug, A. Schumich, U. Potschger, N. Muhlegger, A. Kolenova, K. Reinhardt, and M. Dworzak, 'Blast Cell Deficiency of Cd11a as a Marker of Acute Megakaryoblastic Leukemia and Transient Myeloproliferative Disease in Children with and without Down Syndrome', Cytometry B Clin Cytom, 84 (2013), 370-8.

F. Brackmann, M. Krumbholz, T. Langer, W. Rascher, W. Holter, and M. Metzler, 'Novel Mll2 Mutation in Kabuki Syndrome with Hypogammaglobulinemia and Severe Chronic Thrombopenia', J Pediatr Hematol Oncol, 35 (2013), e314-6.

E. A. Coenen, C. M. Zwaan, D. Reinhardt, C. J. Harrison, O. A. Haas, V. de Haas, V. Mihal, B. De Moerloose, M. Jeison, J. E. Rubnitz, D. Tomizawa, D. Johnston, T. A. Alonzo, H. Hasle, A. Auvrignon, M. Dworzak, A. Pession, V. H. van der Velden, J. Swansbury, K. F. Wong, K. Terui, S. Savasan, M. Winstanley, G. Vaitkeviciene, M. Zimmermann, R. Pieters, and M. M. van den Heuvel-Eibrink, 'Pediatric Acute Myeloid Leukemia with T(8;16)(P11;P13), a Distinct Clinical and Biological Entity: A Collaborative Study by the International-Berlin-Frankfurt-Munster Aml-Study Group', Blood, 122 (2013), 2704-13.

U. Creutzig, M. Zimmermann, J. P. Bourquin, M. N. Dworzak, G. Fleischhack, N. Graf, T. Klingebiel, B. Kremens, T. Lehrnbecher, C. von Neuhoff, J. Ritter, A. Sander, A. Schrauder, A. von Stackelberg, J. Stary, and D. Reinhardt, 'Randomized Trial Comparing Liposomal Daunorubicin with Idarubicin as Induction for Pediatric Acute Myeloid Leukemia: Results from Study Aml-Bfm 2004', Blood, 122 (2013), 37-43.

U. Creutzig, M. Zimmermann, M. N. Dworzak, J. Ritter, G. Schellong, and D. Reinhardt, 'Development of a Curative Treatment within the Aml-Bfm Studies', Klin Padiatr, 225 Suppl 1 (2013), S79-86.

T. M. Dantonello, C. Int-Veen, A. Schuck, G. Seitz, I. Leuschner, M. Nathrath, P. G. Schlegel, U. Kontny, W. Behnisch, I. Veit-Friedrich, S. Kube, E. Hallmen, B. Kazanowska, R. Ladenstein, M. Paulussen, G. Ljungman, S. S. Bielack, T. Klingebiel, E. Koscielniak, and Studiengruppe Cooperative Weichteilsarkom, 'Survival Following Disease Recurrence of Primary Localized Alveolar Rhabdomyosarcoma', Pediatr Blood Cancer, 60 (2013), 1267-73.

C. Eckert, G. Henze, K. Seeger, N. Hagedorn, G. Mann, R. Panzer-Grumayer, C. Peters, T. Klingebiel, A. Borkhardt, M. Schrappe, A. Schrauder, G. Escherich, L. Sramkova, F. Niggli, J. Hitzler, and A. von Stackelberg, 'Use of Allogeneic Hematopoietic Stem-Cell Transplantation Based on Minimal Residual Disease Response Improves Outcomes for Children with Relapsed Acute Lymphoblastic Leukemia in the Intermediate-Risk Group', J Clin Oncol, 31 (2013), 2736-42.

M. N. Gaze, T. Boterberg, K. Dieckmann, M. Hormann, J. E. Gains, K. P. Sullivan, and R. Ladenstein, 'Results of a Quality Assurance Review of External Beam Radiation Therapy in the International Society of Paediatric Oncology (Europe) Neuroblastoma Group's High-Risk Neuroblastoma Trial: A Siopen Study', Int J Radiat Oncol Biol Phys, 85 (2013), 170-4.

R. Geyeregger, C. Freimuller, S. Stevanovic, J. Stemberger, G. Mester, J. Dmytrus, T. Lion, H. G. Rammensee, G. Fischer, B. Eiz-Vesper, A. Lawitschka, S. Matthes, and G. Fritsch, 'Short-Term in-Vitro Expansion Improves Monitoring and Allows Affordable Generation of Virus-Specific T-Cells against Several Viruses for a Broad Clinical Application', PLoS One, 8 (2013), e59592.

M. Ibrisimovic, D. Kneidinger, T. Lion, and R. Klein, 'An Adenoviral Vector-Based Expression and Delivery System for the Inhibition of Wild-Type Adenovirus Replication by Artificial Micrornas', Antiviral Res, 97 (2013), 10-23.

M. Ibrisimovic, T. Lion, and R. Klein, 'Combinatorial Targeting of 2 Different Steps in Adenoviral DNA Replication by Herpes Simplex Virus Thymidine Kinase and Artificial Microrna Expression for the Inhibition of Virus Multiplication in the Presence of Ganciclovir', BMC Biotechnol, 13 (2013), 54.

G. J. Kaspers, M. Zimmermann, D. Reinhardt, B. E. Gibson, R. Y. Tamminga, O. Aleinikova, H. Armendariz, M. Dworzak, S. Y. Ha, H. Hasle, L. Hovi, A. Maschan, Y. Bertrand, G. G. Leverger, B. I. Razzouk, C. Rizzari, P. Smisek, O. Smith, B. Stark, and U. Creutzig, 'Improved Outcome in Pediatric Relapsed Acute Myeloid Leukemia: Results of a Randomized Trial on Liposomal Daunorubicin by the International Bfm Study Group', J Clin Oncol, 31 (2013), 599-607.

C. Kirby, P. F. Ambros, D. Billiter, W. B. London, E. Mendonca, T. Monclair, A. D. Pearson, S. L. Cohn, and S. L. Volchenboum, 'Development of an Open-Source, Flexible Framework for Complex Inter-Institutional Disparate Data Sharing and Collaboration', AMIA Jt Summits Transl Sci Proc, 2013 (2013), 103.

R. Ladenstein, S. Weixler, B. Baykan, M. Bleeke, R. Kunert, D. Katinger, I. Pribill, P. Glander, S. Bauer, V. Pistoia, J. Michon, A. Garaventa, and H. N. Lode, 'Ch14.18 Antibody Produced in Cho Cells in Relapsed or Refractory Stage 4 Neuroblastoma Patients: A Siopen Phase 1 Study', MAbs, 5 (2013), 801-9.

T. Lion, G. Webersinke, U. Kastner, C. Seger, G. Mitterbauer-Hohendanner, and G. Gastl, '[Current Diagnostic Requirements in Chronic Myeloid Leukemia]', Wien Med Wochenschr, 163 (2013), 477-94.

M. Ludwig, E. Enzenhofer, S. Schneider, M. Rauch, A. Bodenteich, K. Neumann, E. Prieschl-Grassauer, A. Grassauer, T. Lion, and C. A. Mueller, 'Efficacy of a Carrageenan Nasal Spray in Patients with Common Cold: A Randomized Controlled Trial', Respir Res, 14 (2013), 124.

R. Luger, S. Valookaran, N. Knapp, C. Vizzardelli, A. M. Dohnal, and T. Felzmann, 'Toll-Like Receptor 4 Engagement Drives Differentiation of Human and Murine Dendritic Cells from a Pro- into an Anti-Inflammatory Mode', PLoS One, 8 (2013), e54879.

S. Matthes-Martin, H. Boztug, and T. Lion, 'Diagnosis and Treatment of Adenovirus Infection in Immunocompromised Patients', Expert Rev Anti Infect Ther, 11 (2013), 1017-28.

S. Matthes-Martin, A. Lawitschka, G. Fritsch, T. Lion, B. Grimm, S. Breuer, H. Boztug, S. Karlhuber, W. Holter, C. Peters, and M. Minkov, 'Stem Cell Transplantation after Reduced-Intensity Conditioning for Sickle Cell Disease', Eur J Haematol, 90 (2013), 308-12.

E. Mayer, M. Holzl, S. Ahmadi, B. Dillinger, N. Pilat, D. Fuchs, T. Wekerle, and A. Heitger, 'Ctla4-Ig Immunosuppressive Activity at the Level of Dendritic Cell/T Cell Crosstalk', Int Immunopharmacol, 15 (2013), 638-45.

C. Meyer, J. Hofmann, T. Burmeister, D. Groger, T. S. Park, M. Emerenciano, M. Pombo de Oliveira, A. Renneville, P. Villarese, E. Macintyre, H. Cave, E. Clappier, K. Mass-Malo, J. Zuna, J. Trka, E. De Braekeleer, M. De Braekeleer, S. H. Oh, G. Tsaur, L. Fechina, V. H. van der Velden, J. J. van Dongen, E. Delabesse, R. Binato, M. L. Silva, A. Kustanovich, O. Aleinikova, M. H. Harris, T. Lund-Aho, V. Juvonen, O. Heidenreich, J. Vormoor, W. W. Choi, M. Jarosova, A. Kolenova, C. Bueno, P. Menendez, S. Wehner, C. Eckert, P. Talmant, S. Tondeur, E. Lippert, E. Launay, C. Henry, P. Ballerini, H. Lapillone, M. B. Callanan, J. M. Cayuela, C. Herbaux, G. Cazzaniga, P. M. Kakadiya, S. Bohlander, M. Ahlmann, J. R. Choi, P. Gameiro, D. S. Lee, J. Krauter, P. Cornillet-Lefebvre, G. Te Kronnie, B. W. Schafer, S. Kubetzko, C. N. Alonso, U. zur Stadt, R. Sutton, N. C. Venn, S. Izraeli, L. Trakhtenbrot, H. O. Madsen, P. Archer, J. Hancock, N. Cerveira, M. R. Teixeira, L. Lo Nigro, A. Moricke, M. Stanulla, M. Schrappe, L. Sedek, T. Szczepanski, C. M. Zwaan, E. A. Coenen, M. M. van den Heuvel-Eibrink, S. Strehl, M. Dworzak, R. Panzer-Grumayer, T. Dingermann, T. Klingebiel, and R. Marschalek, 'The Mll Recombinome of Acute Leukemias in 2013', Leukemia, 27 (2013), 2165-76.

M. Morak, C. Meyer, R. Marschalek, G. Mann, O. A. Haas, and R. Panzer-Grumayer, 'Clone-Specific Secondary Aberrations Are Not Detected in Neonatal Blood Spots of Children with Etv6-Runx1-Positive Leukemia', Haematologica, 98 (2013), e108-10.

E. Muller, M. G. Seidel, H. Lackner, M. Dworzak, and C. Urban, 'Acute Promyelocytic Leukemia Complicated by Massive Intracerebral Hemorrhage: Safety and Efficacy of Replacing Conventional Chemotherapy with Arsenic Trioxide in an Adolescent', Klin Padiatr, 225 (2013), 172-3.

H. Pichler, B. Reismuller, M. Steiner, M. N. Dworzak, U. Potschger, C. Urban, B. Meister, K. Schmitt, R. Panzer-Grumayer, O. A. Haas, A. Attarbaschi, G. Mann, and A. L. L. B. F. M. Study Group Austrian, 'The Inferior Prognosis of Adolescents with Acute Lymphoblastic Leukaemia (All) Is Caused by a Higher Rate of Treatment-Related Mortality and Not an Increased Relapse Rate--a Population-Based Analysis of 25 Years of the Austrian All-Bfm (Berlin-Frankfurt-Munster) Study Group', Br J Haematol, 161 (2013), 556-65.

S. Preuner, and T. Lion, 'Species-Specific Identification of a Wide Range of Clinically Relevant Fungal Pathogens by the Luminex((R)) Xmap Technology', Methods Mol Biol, 968 (2013), 119-39.

B. Reismuller, C. Peters, M. N. Dworzak, U. Potschger, C. Urban, B. Meister, K. Schmitt, K. Dieckmann, H. Gadner, A. Attarbaschi, G. Mann, and A. L. L. B. F. M. Study Group Austrian, 'Outcome of Children and Adolescents with a Second or Third Relapse of Acute Lymphoblastic Leukemia (All): A Population-Based Analysis of the Austrian All-Bfm (Berlin-Frankfurt-Munster) Study Group', J Pediatr Hematol Oncol, 35 (2013), e200-4.

E. Salzer, S. Daschkey, S. Choo, M. Gombert, E. Santos-Valente, S. Ginzel, M. Schwendinger, O. A. Haas, G. Fritsch, W. F. Pickl, E. Forster-Waldl, A. Borkhardt, K. Boztug, K. Bienemann, and M. G. Seidel, 'Combined Immunodeficiency with Life-Threatening Ebv-Associated Lymphoproliferative Disorder in Patients Lacking Functional Cd27', Haematologica, 98 (2013), 473-8.

E. Salzer, E. Santos-Valente, S. Klaver, S. A. Ban, W. Emminger, N. K. Prengemann, W. Garncarz, L. Mullauer, R. Kain, H. Boztug, A. Heitger, K. Arbeiter, F. Eitelberger, M. G. Seidel, W. Holter, A. Pollak, W. F. Pickl, E. Forster-Waldl, and K. Boztug, 'B-Cell Deficiency and Severe Autoimmunity Caused by Deficiency of Protein Kinase C Delta', Blood, 121 (2013), 3112-6.

B. W. Schafer, E. Koscielniak, H. Kovar, and S. Fulda, 'Esf-Embo Symposium "Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence" Sept 29-Oct 4, Polonia Castle Pultusk, Poland', Front Oncol, 3 (2013), 142.

R. K. Schultz, K. S. Baker, J. J. Boelens, C. M. Bollard, R. M. Egeler, M. Cowan, R. Ladenstein, A. Lankester, F. Locatelli, A. Lawitschka, J. E. Levine, M. Loh, E. Nemecek, C. Niemeyer, V. K. Prasad, V. Rocha, S. Shenoy, B. Strahm, P. Veys, D. Wall, P. Bader, S. A. Grupp, M. A. Pulsipher, and C. Peters, 'Challenges and Opportunities for International Cooperative Studies in Pediatric Hematopoeitic Cell Transplantation: Priorities of the Westhafen Intercontinental Group', Biol Blood Marrow Transplant, 19 (2013), 1279-87.

S. Strehl, M. Konig, H. Boztug, B. W. Cooper, K. Suzukawa, S. J. Zhang, H. Y. Chen, A. Attarbaschi, and M. N. Dworzak, 'All-Trans Retinoic Acid and Arsenic Trioxide Resistance of Acute Promyelocytic Leukemia with the Variant Stat5b-Rara Fusion Gene', Leukemia, 27 (2013), 1606-10.

M. M. Strioga, T. Felzmann, D. J. Powell, Jr., V. Ostapenko, N. T. Dobrovolskiene, M. Matuskova, J. Michalek, and V. E. Schijns, 'Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art', Crit Rev Immunol, 33 (2013), 489-547.

R. Sullivan, J. R. Kowalczyk, B. Agarwal, R. Ladenstein, E. Fitzgerald, R. Barr, E. Steliarova-Foucher, I. Magrath, S. C. Howard, M. Kruger, M. G. Valsecchi, A. Biondi, P. Grundy, M. A. Smith, P. Adamson, G. Vassal, and K. Pritchard-Jones, 'New Policies to Address the Global Burden of Childhood Cancers', Lancet Oncol, 14 (2013), e125-35.

I. van der Sluis, A. Moricke, G. Escherich, A. von Stackelberg, W. Holter, T. Klingebiel, C. Flotho, S. Legien, W. Tissing, M. Bierings, C. Guimbal-Schmolck, U. Pichlmeier, H. J. Kuhnel, and R. Pieters, 'Pediatric Acute Lymphoblastic Leukemia: Efficacy and Safety of Recombinant E. Coli-Asparaginase in Infants (Less Than One Year of Age) with Acute Lymphoblastic Leukemia', Haematologica, 98 (2013), 1697-701.

C. M. Zwaan, C. Rizzari, F. Mechinaud, D. L. Lancaster, T. Lehrnbecher, V. H. van der Velden, B. B. Beverloo, M. L. den Boer, R. Pieters, D. Reinhardt, M. Dworzak, J. Rosenberg, G. Manos, S. Agrawal, L. Strauss, A. Baruchel, and P. R. Kearns, 'Dasatinib in Children and Adolescents with Relapsed or Refractory Leukemia: Results of the Ca180-018 Phase I Dose-Escalation Study of the Innovative Therapies for Children with Cancer Consortium', J Clin Oncol, 31 (2013), 2460-8.

CCRI Publications 2012

P. Angelini, W. B. London, S. L. Cohn, A. D. Pearson, K. K. Matthay, T. Monclair, P. F. Ambros, H. Shimada, I. Leuschner, M. Peuchmaur, M. S. Irwin, and S. Baruchel, 'Characteristics and Outcome of Patients with Ganglioneuroblastoma, Nodular Subtype: A Report from the Inrg Project', Eur J Cancer, 48 (2012), 1185-91.

A. Attarbaschi, M. Morak, G. Cario, G. Cazzaniga, H. M. Ensor, T. te Kronnie, J. Bradtke, G. Mann, E. Vendramini, C. Palmi, C. Schwab, L. J. Russell, M. Schrappe, V. Conter, C. D. Mitchell, S. Strehl, M. Zimmermann, U. Potschger, C. J. Harrison, M. Stanulla, R. Panzer-Grumayer, O. A. Haas, A. V. Moorman, Group Associazione Italiana di Ematologia ed Oncologia Pediatrica -Berlin-Frankfurt-Munster Study, Cancer National Cancer Research Institute -Children's, and Group Leukaemia Study, 'Treatment Outcome of Crlf2-Rearranged Childhood Acute Lymphoblastic Leukaemia: A Comparative Analysis of the Aieop-Bfm and Uk Ncri-Cclg Study Groups', Br J Haematol, 158 (2012), 772-7.

I. M. Bennani-Baiti, I. Machado, A. Llombart-Bosch, and H. Kovar, 'Lysine-Specific Demethylase 1 (Lsd1/Kdm1a/Aof2/Bhc110) Is Expressed and Is an Epigenetic Drug Target in Chondrosarcoma, Ewing's Sarcoma, Osteosarcoma, and Rhabdomyosarcoma', Hum Pathol, 43 (2012), 1300-7.

A. Borgmann-Staudt, R. Rendtorff, S. Reinmuth, C. Hohmann, T. Keil, F. R. Schuster, W. Holter, K. Ehlert, P. Keslova, A. Lawitschka, A. Jarisch, and G. Strauss, 'Fertility after Allogeneic Haematopoietic Stem Cell Transplantation in Childhood and Adolescence', Bone Marrow Transplant, 47 (2012), 271-6.

F. Brackmann, H. G. Dorr, C. R. Bartram, K. Hinderhofer, W. Holter, and T. Langer, 'Glucocorticoid Withdrawal - Heterozygous Carriers of Congenital Adrenal Hyperplasia at Risk?', Klin Padiatr, 224 (2012), 392-3.

I. B. Brecht, A. Agaimy, M. Besendorfer, R. Carbon, F. C. Thiel, O. Rompel, D. Osinski, T. Langer, M. Metzler, and W. Holter, 'Malignant Peritoneal Mesothelioma in a 16-Year-Old Girl: Presentation of a Rare Disease', Klin Padiatr, 224 (2012), 170-3.

S. Breuer, S. Preuner, G. Fritsch, H. Daxberger, M. Koenig, U. Poetschger, A. Lawitschka, C. Peters, G. Mann, T. Lion, and S. Matthes-Martin, 'Early Recipient Chimerism Testing in the T- and Nk-Cell Lineages for Risk Assessment of Graft Rejection in Pediatric Patients Undergoing Allogeneic Stem Cell Transplantation', Leukemia, 26 (2012), 509-19.

S. Breuer, M. Rauch, S. Matthes-Martin, and T. Lion, 'Molecular Diagnosis and Management of Viral Infections in Hematopoietic Stem Cell Transplant Recipients', Mol Diagn Ther, 16 (2012), 63-77.

U. Creutzig, M. M. van den Heuvel-Eibrink, B. Gibson, M. N. Dworzak, S. Adachi, E. de Bont, J. Harbott, H. Hasle, D. Johnston, A. Kinoshita, T. Lehrnbecher, G. Leverger, E. Mejstrikova, S. Meshinchi, A. Pession, S. C. Raimondi, L. Sung, J. Stary, C. M. Zwaan, G. J. Kaspers, D. Reinhardt, and A. M. L. Committee of the International BFM Study Group, 'Diagnosis and Management of Acute Myeloid Leukemia in Children and Adolescents: Recommendations from an International Expert Panel', Blood, 120 (2012), 3187-205.

U. Creutzig, M. Zimmermann, J. P. Bourquin, M. N. Dworzak, B. Kremens, T. Lehrnbecher, C. von Neuhoff, A. Sander, A. von Stackelberg, I. Schmid, J. Stary, D. Steinbach, J. Vormoor, and D. Reinhardt, 'Favorable Outcome in Infants with Aml after Intensive First- and Second-Line Treatment: An Aml-Bfm Study Group Report', Leukemia, 26 (2012), 654-61.

A. Decock, M. Ongenaert, J. Hoebeeck, K. De Preter, G. Van Peer, W. Van Criekinge, R. Ladenstein, J. H. Schulte, R. Noguera, R. L. Stallings, A. Van Damme, G. Laureys, J. Vermeulen, T. Van Maerken, F. Speleman, and J. Vandesompele, 'Genome-Wide Promoter Methylation Analysis in Neuroblastoma Identifies Prognostic Methylation Biomarkers', Genome Biol, 13 (2012), R95.

D. Denk, K. Nebral, J. Bradtke, G. Pass, A. Moricke, A. Attarbaschi, and S. Strehl, 'Pax5-Auts2: A Recurrent Fusion Gene in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia', Leuk Res, 36 (2012), e178-81.

E. Ellinghaus, M. Stanulla, G. Richter, D. Ellinghaus, G. te Kronnie, G. Cario, G. Cazzaniga, M. Horstmann, R. Panzer Grumayer, H. Cave, J. Trka, O. Cinek, A. Teigler-Schlegel, A. ElSharawy, R. Hasler, A. Nebel, B. Meissner, T. Bartram, F. Lescai, C. Franceschi, M. Giordan, P. Nurnberg, B. Heinzow, M. Zimmermann, S. Schreiber, M. Schrappe, and A. Franke, 'Identification of Germline Susceptibility Loci in Etv6-Runx1-Rearranged Childhood Acute Lymphoblastic Leukemia', Leukemia, 26 (2012), 902-9.

T. Fazekas, P. Eickhoff, N. Pruckner, G. Vollnhofer, G. Fischmeister, C. Diakos, M. Rauch, M. Verdianz, A. Zoubek, H. Gadner, and T. Lion, 'Lessons Learned from a Double-Blind Randomised Placebo-Controlled Study with a Iota-Carrageenan Nasal Spray as Medical Device in Children with Acute Symptoms of Common Cold', BMC Complement Altern Med, 12 (2012), 147.

T. Fazekas, P. Eickhoff, M. Rauch, M. Verdianz, A. Attarbaschi, M. Dworzak, C. Peters, K. Hammer, A. Vecsei, U. Potschger, and T. Lion, 'Prevalence and Clinical Course of Viral Upper Respiratory Tract Infections in Immunocompromised Pediatric Patients with Malignancies or after Hematopoietic Stem Cell Transplantation', J Pediatr Hematol Oncol, 34 (2012), 442-9.

K. Fiser, T. Sieger, A. Schumich, B. Wood, J. Irving, E. Mejstrikova, and M. N. Dworzak, 'Detection and Monitoring of Normal and Leukemic Cell Populations with Hierarchical Clustering of Flow Cytometry Data', Cytometry A, 81 (2012), 25-34.

G. Fritsch, V. Witt, H. P. Spengler, J. Pichler, D. Scharner, E. Zipperer, D. Trbojevic, J. Stemberger, R. Geyeregger, M. K. Tea, and D. Printz, 'Robust Multi-Parameter Single-Platform Quantification of Myeloid and B-Lymphoid Cd34 Progenitor Cells in All Clinical Cd34 Cell Sources and in Thawed Pbsc', Pediatr Hematol Oncol, 29 (2012), 595-610.

G. Fuka, H. P. Kantner, R. Grausenburger, A. Inthal, E. Bauer, G. Krapf, U. Kaindl, M. Kauer, M. N. Dworzak, D. Stoiber, O. A. Haas, and R. Panzer-Grumayer, 'Silencing of Etv6/Runx1 Abrogates Pi3k/Akt/Mtor Signaling and Impairs Reconstitution of Leukemia in Xenografts', Leukemia, 26 (2012), 927-33.

G. Gaipa, G. Cazzaniga, M. G. Valsecchi, R. Panzer-Grumayer, B. Buldini, D. Silvestri, L. Karawajew, O. Maglia, R. Ratei, A. Benetello, S. Sala, A. Schumich, A. Schrauder, T. Villa, M. Veltroni, W. D. Ludwig, V. Conter, M. Schrappe, A. Biondi, M. N. Dworzak, and G. Basso, 'Time Point-Dependent Concordance of Flow Cytometry and Real-Time Quantitative Polymerase Chain Reaction for Minimal Residual Disease Detection in Childhood Acute Lymphoblastic Leukemia', Haematologica, 97 (2012), 1582-93.

S. Heitzeneder, M. Seidel, E. Forster-Waldl, and A. Heitger, 'Mannan-Binding Lectin Deficiency - Good News, Bad News, Doesn't Matter?', Clin Immunol, 143 (2012), 22-38.

S. Hirabayashi, C. Flotho, J. Moetter, M. Heuser, H. Hasle, B. Gruhn, T. Klingebiel, F. Thol, B. Schlegelberger, I. Baumann, B. Strahm, J. Stary, F. Locatelli, M. Zecca, E. Bergstraesser, M. Dworzak, M. M. van den Heuvel-Eibrink, B. De Moerloose, S. Ogawa, C. M. Niemeyer, M. W. Wlodarski, and M. D. S. in Childhood European Working Group of, 'Spliceosomal Gene Aberrations Are Rare, Coexist with Oncogenic Mutations, and Are Unlikely to Exert a Driver Effect in Childhood Mds and Jmml', Blood, 119 (2012), e96-9.

Z. Husak, and M. N. Dworzak, 'Cd99 Ligation Upregulates Hsp70 on Acute Lymphoblastic Leukemia Cells and Concomitantly Increases Nk Cytotoxicity', Cell Death Dis, 3 (2012), e425.

C. Hutter, M. Kauer, I. Simonitsch-Klupp, G. Jug, R. Schwentner, J. Leitner, P. Bock, P. Steinberger, W. Bauer, N. Carlesso, M. Minkov, H. Gadner, G. Stingl, H. Kovar, and E. Kriehuber, 'Notch Is Active in Langerhans Cell Histiocytosis and Confers Pathognomonic Features on Dendritic Cells', Blood, 120 (2012), 5199-208.

M. Ibrisimovic, U. Nagl, D. Kneidinger, M. Rauch, T. Lion, and R. Klein, 'Targeted Expression of Herpes Simplex Virus Thymidine Kinase in Adenovirus-Infected Cells Reduces Virus Titers Upon Treatment with Ganciclovir in Vitro', J Gene Med, 14 (2012), 3-19.

A. Inthal, P. Zeitlhofer, M. Zeginigg, M. Morak, R. Grausenburger, E. Fronkova, B. Fahrner, G. Mann, O. A. Haas, and R. Panzer-Grumayer, 'Crebbp Hat Domain Mutations Prevail in Relapse Cases of High Hyperdiploid Childhood Acute Lymphoblastic Leukemia', Leukemia, 26 (2012), 1797-803.

J. H. Klusmann, D. Reinhardt, M. Zimmermann, B. Kremens, J. Vormoor, M. Dworzak, U. Creutzig, and T. Klingebiel, 'The Role of Matched Sibling Donor Allogeneic Stem Cell Transplantation in Pediatric High-Risk Acute Myeloid Leukemia: Results from the Aml-Bfm 98 Study', Haematologica, 97 (2012), 21-9.

D. Kneidinger, M. Ibrisimovic, T. Lion, and R. Klein, 'Inhibition of Adenovirus Multiplication by Short Interfering Rnas Directly or Indirectly Targeting the Viral DNA Replication Machinery', Antiviral Res, 94 (2012), 195-207.

H. Kovar, J. Alonso, P. Aman, D. N. Aryee, J. Ban, S. A. Burchill, S. Burdach, E. De Alava, O. Delattre, U. Dirksen, A. Fourtouna, S. Fulda, L. J. Helman, D. Herrero-Martin, P. C. Hogendoorn, U. Kontny, E. R. Lawlor, S. L. Lessnick, A. Llombart-Bosch, M. Metzler, R. Moriggl, S. Niedan, J. Potratz, F. Redini, G. H. Richter, L. T. Riedmann, C. Rossig, B. W. Schafer, R. Schwentner, K. Scotlandi, P. H. Sorensen, M. S. Staege, F. Tirode, J. Toretsky, S. Ventura, A. Eggert, and R. Ladenstein, 'The First European Interdisciplinary Ewing Sarcoma Research Summit', Front Oncol, 2 (2012), 54.

M. Lanzinger, B. Jurgens, U. Hainz, B. Dillinger, J. Raberger, D. Fuchs, and A. Heitger, 'Ambivalent Effects of Dendritic Cells Displaying Prostaglandin E2-Induced Indoleamine 2,3-Dioxygenase', Eur J Immunol, 42 (2012), 1117-28.

M. Lehner, G. Gotz, J. Proff, N. Schaft, J. Dorrie, F. Full, A. Ensser, Y. A. Muller, A. Cerwenka, H. Abken, O. Parolini, P. F. Ambros, H. Kovar, and W. Holter, 'Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric Nkg2d Receptor Expressed by Lentiviral Transduction or Mrna Transfection', PLoS One, 7 (2012), e31210.

M. Lehner, B. Kellert, J. Proff, M. A. Schmid, P. Diessenbacher, A. Ensser, J. Dorrie, N. Schaft, M. Leverkus, E. Kampgen, and W. Holter, 'Autocrine Tnf Is Critical for the Survival of Human Dendritic Cells by Regulating Bak, Bcl-2, and Flipl', J Immunol, 188 (2012), 4810-8.

T. W. Lion, and R. J. Allen, 'Computing the Local Pressure in Molecular Dynamics Simulations', J Phys Condens Matter, 24 (2012), 284133.

T. Lion, F. Watzinger, S. Preuner, H. Kreyenberg, M. Tilanus, R. de Weger, J. van Loon, L. de Vries, H. Cave, C. Acquaviva, M. Lawler, M. Crampe, A. Serra, B. Saglio, F. Colnaghi, A. Biondi, J. J. van Dongen, M. van der Burg, M. Gonzalez, M. Alcoceba, G. Barbany, M. Hermanson, E. Roosnek, C. Steward, J. Harvey, F. Frommlet, and P. Bader, 'The Eurochimerism Concept for a Standardized Approach to Chimerism Analysis after Allogeneic Stem Cell Transplantation', Leukemia, 26 (2012), 1821-8.

M. Morak, A. Attarbaschi, S. Fischer, C. Nassimbeni, R. Grausenburger, S. Bastelberger, S. Krentz, G. Cario, D. Kasper, K. Schmitt, L. J. Russell, U. Potschger, M. Stanulla, C. Eckert, G. Mann, O. A. Haas, and R. Panzer-Grumayer, 'Small Sizes and Indolent Evolutionary Dynamics Challenge the Potential Role of P2ry8-Crlf2-Harboring Clones as Main Relapse-Driving Force in Childhood All', Blood, 120 (2012), 5134-42.

N. Naumann-Bartsch, R. Carbon, P. Klein, A. Agaimy, W. Holter, and J. Jungert, 'An Unusual Thyroid Mass in a 5-Year-Old Girl', J Pediatr, 161 (2012), 565.

H. Pichler, P. Zeitlhofer, M. N. Dworzak, C. Diakos, O. A. Haas, and L. Kager, 'Thiamine-Responsive Megaloblastic Anemia (Trma) in an Austrian Boy with Compound Heterozygous Slc19a2 Mutations', Eur J Pediatr, 171 (2012), 1711-5.

S. Postel-Vinay, A. S. Veron, F. Tirode, G. Pierron, S. Reynaud, H. Kovar, O. Oberlin, E. Lapouble, S. Ballet, C. Lucchesi, U. Kontny, A. Gonzalez-Neira, P. Picci, J. Alonso, A. Patino-Garcia, B. B. de Paillerets, K. Laud, C. Dina, P. Froguel, F. Clavel-Chapelon, F. Doz, J. Michon, S. J. Chanock, G. Thomas, D. G. Cox, and O. Delattre, 'Common Variants near Tardbp and Egr2 Are Associated with Susceptibility to Ewing Sarcoma', Nat Genet, 44 (2012), 323-7.

S. Preuner, G. Mitterbauer, C. Mannhalter, S. Herndlhofer, W. R. Sperr, P. Valent, and T. Lion, 'Quantitative Monitoring of Bcr/Abl1 Mutants for Surveillance of Subclone-Evolution, -Expansion, and -Depletion in Chronic Myeloid Leukaemia', Eur J Cancer, 48 (2012), 233-6.

W. Pulverer, M. Wielscher, R. Panzer-Grumayer, T. Plessl, A. Kriegner, K. Vierlinger, and A. Weinhausel, 'The Stem Cell Signature of Chh/Chg Methylation Is Not Present in 271 Cancer Associated 5'utr Gene Regions', Biochimie, 94 (2012), 2345-52.

M. G. Seidel, B. Rami, C. Item, E. Schober, P. Zeitlhofer, W. D. Huber, A. Heitger, O. A. Bodamer, and O. A. Haas, 'Concurrent Foxp3- and Ctla4-Associated Genetic Predisposition and Skewed X Chromosome Inactivation in an Autoimmune Disease-Prone Family', Eur J Endocrinol, 167 (2012), 131-4.

M. Steiner, D. Hochreiter, D. C. Kasper, R. Kornmuller, H. Pichler, O. A. Haas, U. Potschger, C. Hutter, M. N. Dworzak, G. Mann, and A. Attarbaschi, 'Asparagine and Aspartic Acid Concentrations in Bone Marrow Versus Peripheral Blood During Berlin-Frankfurt-Munster-Based Induction Therapy for Childhood Acute Lymphoblastic Leukemia', Leuk Lymphoma, 53 (2012), 1682-7.

P. Valent, G. Gastl, K. Geissler, R. Greil, O. Hantschel, A. Lang, W. Linkesch, T. Lion, A. L. Petzer, E. Pittermann, L. Pleyer, J. Thaler, and D. Wolf, 'Nilotinib as Frontline and Second-Line Therapy in Chronic Myeloid Leukemia: Open Questions', Crit Rev Oncol Hematol, 82 (2012), 370-7.

G. J. Veal, L. Nguyen, A. Paci, M. Riggi, M. Amiel, D. Valteau-Couanet, P. Brock, R. Ladenstein, and G. Vassal, 'Busulfan Pharmacokinetics Following Intravenous and Oral Dosing Regimens in Children Receiving High-Dose Myeloablative Chemotherapy for High-Risk Neuroblastoma as Part of the Hr-Nbl-1/Siopen Trial', Eur J Cancer, 48 (2012), 3063-72.

CCRI Publications 2011

I. M. Ambros, B. Brunner, G. Aigner, C. Bedwell, K. Beiske, J. Benard, N. Bown, V. Combaret, J. Couturier, R. Defferrari, N. Gross, M. Jeison, J. Lunec, B. Marques, T. Martinsson, K. Mazzocco, R. Noguera, G. Schleiermacher, F. Speleman, R. Stallings, G. P. Tonini, D. A. Tweddle, A. Valent, A. Vicha, N. V. Roy, E. Villamon, A. Ziegler, S. Preuner, M. Drobics, R. Ladenstein, G. Amann, R. J. Schuit, U. Potschger, and P. F. Ambros, 'A Multilocus Technique for Risk Evaluation of Patients with Neuroblastoma', Clin Cancer Res, 17 (2011), 792-804.

J. Ban, G. Jug, P. Mestdagh, R. Schwentner, M. Kauer, D. N. Aryee, K. L. Schaefer, F. Nakatani, K. Scotlandi, M. Reiter, D. Strunk, F. Speleman, J. Vandesompele, and H. Kovar, 'Hsa-Mir-145 Is the Top Ews-Fli1-Repressed Microrna Involved in a Positive Feedback Loop in Ewing's Sarcoma', Oncogene, 30 (2011), 2173-80.

I. M. Bennani-Baiti, D. N. Aryee, J. Ban, I. Machado, M. Kauer, K. Muhlbacher, G. Amann, A. Llombart-Bosch, and H. Kovar, 'Notch Signalling Is Off and Is Uncoupled from Hes1 Expression in Ewing's Sarcoma', J Pathol, 225 (2011), 353-63.

E. A. Coenen, S. C. Raimondi, J. Harbott, M. Zimmermann, T. A. Alonzo, A. Auvrignon, H. B. Beverloo, M. Chang, U. Creutzig, M. N. Dworzak, E. Forestier, B. Gibson, H. Hasle, C. J. Harrison, N. A. Heerema, G. J. Kaspers, A. Leszl, N. Litvinko, L. Lo Nigro, A. Morimoto, C. Perot, D. Reinhardt, J. E. Rubnitz, F. O. Smith, J. Stary, I. Stasevich, S. Strehl, T. Taga, D. Tomizawa, D. Webb, Z. Zemanova, R. Pieters, C. M. Zwaan, and M. M. van den Heuvel-Eibrink, 'Prognostic Significance of Additional Cytogenetic Aberrations in 733 De Novo Pediatric 11q23/Mll-Rearranged Aml Patients: Results of an International Study', Blood, 117 (2011), 7102-11.

U. Creutzig, M. Zimmermann, J. P. Bourquin, M. N. Dworzak, G. Fleischhack, C. von Neuhoff, A. Sander, A. Schrauder, A. von Stackelberg, J. Ritter, J. Stary, and D. Reinhardt, 'Cns Irradiation in Pediatric Acute Myleoid Leukemia: Equal Results by 12 or 18 Gy in Studies Aml-Bfm98 and 2004', Pediatr Blood Cancer, 57 (2011), 986-92.

U. Creutzig, M. Zimmermann, J. P. Bourquin, M. N. Dworzak, C. von Neuhoff, A. Sander, A. Schrauder, A. Teigler-Schlegel, J. Stary, S. Corbacioglu, and D. Reinhardt, 'Second Induction with High-Dose Cytarabine and Mitoxantrone: Different Impact on Pediatric Aml Patients with T(8;21) and with Inv(16)', Blood, 118 (2011), 5409-15.

G. Fuka, M. Kauer, R. Kofler, O. A. Haas, and R. Panzer-Grumayer, 'The Leukemia-Specific Fusion Gene Etv6/Runx1 Perturbs Distinct Key Biological Functions Primarily by Gene Repression', PLoS One, 6 (2011), e26348.

A. Heitger, 'Regulation of Expression and Function of Ido in Human Dendritic Cells', Curr Med Chem, 18 (2011), 2222-33.

H. Kovar, 'Dr. Jekyll and Mr. Hyde: The Two Faces of the Fus/Ews/Taf15 Protein Family', Sarcoma, 2011 (2011), 837474.

L. Kuster, R. Grausenburger, G. Fuka, U. Kaindl, G. Krapf, A. Inthal, G. Mann, M. Kauer, J. Rainer, R. Kofler, A. Hall, M. Metzler, L. H. Meyer, C. Meyer, J. Harbott, R. Marschalek, S. Strehl, O. A. Haas, and R. Panzer-Grumayer, 'Etv6/Runx1-Positive Relapses Evolve from an Ancestral Clone and Frequently Acquire Deletions of Genes Implicated in Glucocorticoid Signaling', Blood, 117 (2011), 2658-67.

R. Ladenstein, U. Potschger, D. Siabalis, A. Garaventa, C. Bergeron, I. J. Lewis, J. Stein, J. Kohler, P. J. Shaw, W. Holter, V. Pistoia, and J. Michon, 'Dose Finding Study for the Use of Subcutaneous Recombinant Interleukin-2 to Augment Natural Killer Cell Numbers in an Outpatient Setting for Stage 4 Neuroblastoma after Megatherapy and Autologous Stem-Cell Reinfusion', J Clin Oncol, 29 (2011), 441-8.

A. Lawitschka, C. Peters, M. G. Seidel, A. Havranek, A. Heitger, T. Fazekas, E. D. Gueclue, H. Gadner, and S. Matthes-Martin, 'Long-Term Remission in Pediatric Wegener Granulomatosis Following Allo-Sct after Reduced-Intensity Conditioning', Bone Marrow Transplant, 46 (2011), 462-3.

S. L. Lessnick, H. Kovar, and P. Houghton, 'The Molecular Basis of Sarcoma', Sarcoma, 2011 (2011), 864130.

W. B. London, V. Castel, T. Monclair, P. F. Ambros, A. D. Pearson, S. L. Cohn, F. Berthold, A. Nakagawara, R. L. Ladenstein, T. Iehara, and K. K. Matthay, 'Clinical and Biologic Features Predictive of Survival after Relapse of Neuroblastoma: A Report from the International Neuroblastoma Risk Group Project', J Clin Oncol, 29 (2011), 3286-92.

V. Moroz, D. Machin, A. Faldum, B. Hero, T. Iehara, V. Mosseri, R. Ladenstein, B. De Bernardi, H. Rubie, F. Berthold, K. K. Matthay, T. Monclair, P. F. Ambros, A. D. Pearson, S. L. Cohn, and W. B. London, 'Changes over Three Decades in Outcome and the Prognostic Influence of Age-at-Diagnosis in Young Patients with Neuroblastoma: A Report from the International Neuroblastoma Risk Group Project', Eur J Cancer, 47 (2011), 561-71.

K. Nebral, D. Krehan, and S. Strehl, 'Expression of Pax5 Splice Variants: A Phenomenon of Stress-Induced, Illegitimate Splicing?', Br J Haematol, 155 (2011), 277-80.

K. Pritchard-Jones, G. Lewison, S. Camporesi, G. Vassal, R. Ladenstein, Y. Benoit, J. S. Predojevic, J. Sterba, J. Stary, T. Eckschlager, H. Schroeder, F. Doz, U. Creutzig, T. Klingebiel, H. V. Kosmidis, M. Garami, R. Pieters, A. O'Meara, G. Dini, R. Riccardi, J. Rascon, L. Rageliene, V. Calvagna, P. Czauderna, J. Kowalczyk, M. J. Gil-da-Costa, L. Norton, F. Pereira, D. Janic, J. Puskacova, J. Jazbec, A. Canete, L. Hjorth, G. Ljungman, T. Kutluk, B. Morland, M. Stevens, D. Walker, and R. Sullivan, 'The State of Research into Children with Cancer across Europe: New Policies for a New Decade', Ecancermedicalscience, 5 (2011), 210.

H. Rubie, B. De Bernardi, M. Gerrard, A. Canete, R. Ladenstein, J. Couturier, P. Ambros, C. Munzer, A. D. Pearson, A. Garaventa, P. Brock, V. Castel, D. Valteau-Couanet, K. Holmes, A. Di Cataldo, B. Brichard, V. Mosseri, C. Marquez, D. Plantaz, L. Boni, and J. Michon, 'Excellent Outcome with Reduced Treatment in Infants with Nonmetastatic and Unresectable Neuroblastoma without Mycn Amplification: Results of the Prospective Ines 99.1', J Clin Oncol, 29 (2011), 449-55.

G. Schleiermacher, J. Michon, A. Ribeiro, G. Pierron, V. Mosseri, H. Rubie, C. Munzer, J. Benard, N. Auger, V. Combaret, I. Janoueix-Lerosey, A. Pearson, D. A. Tweddle, N. Bown, M. Gerrard, K. Wheeler, R. Noguera, E. Villamon, A. Canete, V. Castel, B. Marques, A. de Lacerda, G. P. Tonini, K. Mazzocco, R. Defferrari, B. de Bernardi, A. di Cataldo, N. van Roy, B. Brichard, R. Ladenstein, I. Ambros, P. Ambros, K. Beiske, O. Delattre, and J. Couturier, 'Segmental Chromosomal Alterations Lead to a Higher Risk of Relapse in Infants with Mycn-Non-Amplified Localised Unresectable/Disseminated Neuroblastoma (a Siopen Collaborative Study)', Br J Cancer, 105 (2011), 1940-8.

W. M. Schmidt, M. H. Uddin, S. Dysek, K. Moser-Thier, C. Pirker, H. Hoger, I. M. Ambros, P. F. Ambros, W. Berger, and R. E. Bittner, 'DNA Damage, Somatic Aneuploidy, and Malignant Sarcoma Susceptibility in Muscular Dystrophies', PLoS Genet, 7 (2011), e1002042.

M. Schrappe, M. G. Valsecchi, C. R. Bartram, A. Schrauder, R. Panzer-Grumayer, A. Moricke, R. Parasole, M. Zimmermann, M. Dworzak, B. Buldini, A. Reiter, G. Basso, T. Klingebiel, C. Messina, R. Ratei, G. Cazzaniga, R. Koehler, F. Locatelli, B. W. Schafer, M. Arico, K. Welte, J. J. van Dongen, H. Gadner, A. Biondi, and V. Conter, 'Late Mrd Response Determines Relapse Risk Overall and in Subsets of Childhood T-Cell All: Results of the Aieop-Bfm-All 2000 Study', Blood, 118 (2011), 2077-84.

T. Szczepanski, V. H. van der Velden, E. Waanders, R. P. Kuiper, P. Van Vlierberghe, B. Gruhn, C. Eckert, R. Panzer-Grumayer, G. Basso, H. Cave, U. Z. Stadt, D. Campana, A. Schrauder, R. Sutton, E. van Wering, J. P. Meijerink, and J. J. van Dongen, 'Late Recurrence of Childhood T-Cell Acute Lymphoblastic Leukemia Frequently Represents a Second Leukemia Rather Than a Relapse: First Evidence for Genetic Predisposition', J Clin Oncol, 29 (2011), 1643-9.

D. R. Taggart, W. B. London, M. L. Schmidt, S. G. DuBois, T. F. Monclair, A. Nakagawara, B. De Bernardi, P. F. Ambros, A. D. Pearson, S. L. Cohn, and K. K. Matthay, 'Prognostic Value of the Stage 4s Metastatic Pattern and Tumor Biology in Patients with Metastatic Neuroblastoma Diagnosed between Birth and 18 Months of Age', J Clin Oncol, 29 (2011), 4358-64.

U. Thiel, A. Wawer, P. Wolf, M. Badoglio, A. Santucci, T. Klingebiel, O. Basu, A. Borkhardt, H. J. Laws, Y. Kodera, A. Yoshimi, C. Peters, R. Ladenstein, A. Pession, A. Prete, E. C. Urban, W. Schwinger, P. Bordigoni, A. Salmon, M. A. Diaz, B. Afanasyev, I. Lisukov, E. Morozova, A. Toren, B. Bielorai, J. Korsakas, F. Fagioli, D. Caselli, G. Ehninger, B. Gruhn, U. Dirksen, F. Abdel-Rahman, M. Aglietta, E. Mastrodicasa, M. Torrent, P. Corradini, F. Demeocq, G. Dini, P. Dreger, M. Eyrich, J. Gozdzik, F. Guilhot, E. Holler, E. Koscielniak, C. Messina, D. Nachbaur, R. Sabbatini, E. Oldani, H. Ottinger, H. Ozsahin, R. Schots, S. Siena, J. Stein, S. Sufliarska, A. Unal, M. Ussowicz, P. Schneider, W. Woessmann, H. Jurgens, M. Bregni, S. Burdach, Party Solid Tumor Working, Blood the Pediatric DiseaseWorking Party of the European Group for, Transplantation Marrow, Blood Asia Pacific, Transplantation Marrow, Transplantations Pediatric Registry for Stem Cell, and Eicess Study Group Meta, 'No Improvement of Survival with Reduced- Versus High-Intensity Conditioning for Allogeneic Stem Cell Transplants in Ewing Tumor Patients', Ann Oncol, 22 (2011), 1614-21.

M. van der Burg, H. Kreyenberg, A. Willasch, B. H. Barendregt, S. Preuner, F. Watzinger, T. Lion, E. Roosnek, J. Harvey, M. Alcoceba, M. G. Diaz, P. Bader, J. J. van Dongen, and E. U-supported EuroChimerism Consortium project QLRT, 'Standardization of DNA Isolation from Low Cell Numbers for Chimerism Analysis by Pcr of Short Tandem Repeats', Leukemia, 25 (2011), 1467-70.

W. Warsch, K. Kollmann, E. Eckelhart, S. Fajmann, S. Cerny-Reiterer, A. Holbl, K. V. Gleixner, M. Dworzak, M. Mayerhofer, G. Hoermann, H. Herrmann, C. Sillaber, G. Egger, P. Valent, R. Moriggl, and V. Sexl, 'High Stat5 Levels Mediate Imatinib Resistance and Indicate Disease Progression in Chronic Myeloid Leukemia', Blood, 117 (2011), 3409-20.

G. E. Winter, U. Rix, A. Lissat, A. Stukalov, M. K. Mullner, K. L. Bennett, J. Colinge, S. M. Nijman, S. Kubicek, H. Kovar, U. Kontny, and G. Superti-Furga, 'An Integrated Chemical Biology Approach Identifies Specific Vulnerability of Ewing's Sarcoma to Combined Inhibition of Aurora Kinases a and B', Mol Cancer Ther, 10 (2011), 1846-56.

V. Witt, E. Beiglbock, and G. Fritsch, 'Bone Marrow Processing with the Amicus Separator System', J Clin Apher, 26 (2011), 195-9.

M. W. Wlodarski, J. Motter, T. A. Gorr, C. Olk-Batz, H. Hasle, M. Dworzak, C. M. Niemeyer, and C. Flotho, 'Abnormal Promoter DNA Methylation in Juvenile Myelomonocytic Leukemia Is Not Caused by Mutation in Dnmt3a', Blood, 118 (2011), 4490-1.

CCRI Publications 2010

D. N. Aryee, S. Niedan, M. Kauer, R. Schwentner, I. M. Bennani-Baiti, J. Ban, K. Muehlbacher, M. Kreppel, R. L. Walker, P. Meltzer, C. Poremba, R. Kofler, and H. Kovar, 'Hypoxia Modulates Ews-Fli1 Transcriptional Signature and Enhances the Malignant Properties of Ewing's Sarcoma Cells in Vitro', Cancer Res, 70 (2010), 4015-23.

A. Attarbaschi, M. Pisecker, A. Inthal, G. Mann, D. Janousek, M. Dworzak, U. Potschger, R. Ullmann, M. Schrappe, H. Gadner, O. A. Haas, R. Panzer-Grumayer, S. Strehl, and Group Austrian Berlin-Frankfurt-Munster Study, 'Prognostic Relevance of Tlx3 (Hox11l2) Expression in Childhood T-Cell Acute Lymphoblastic Leukaemia Treated with Berlin-Frankfurt-Munster (Bfm) Protocols Containing Early and Late Re-Intensification Elements', Br J Haematol, 148 (2010), 293-300.

I. M. Bennani-Baiti, A. Cooper, E. R. Lawlor, M. Kauer, J. Ban, D. N. Aryee, and H. Kovar, 'Intercohort Gene Expression Co-Analysis Reveals Chemokine Receptors as Prognostic Indicators in Ewing's Sarcoma', Clin Cancer Res, 16 (2010), 3769-78.

M. Bruggemann, A. Schrauder, T. Raff, H. Pfeifer, M. Dworzak, O. G. Ottmann, V. Asnafi, A. Baruchel, R. Bassan, Y. Benoit, A. Biondi, H. Cave, H. Dombret, A. K. Fielding, R. Foa, N. Gokbuget, A. H. Goldstone, N. Goulden, G. Henze, D. Hoelzer, G. E. Janka-Schaub, E. A. Macintyre, R. Pieters, A. Rambaldi, J. M. Ribera, K. Schmiegelow, O. Spinelli, J. Stary, A. von Stackelberg, M. Kneba, M. Schrappe, J. J. van Dongen, Leukemia European Working Group for Adult Acute Lymphoblastic, and Group International Berlin-Frankfurt-Munster Study, 'Standardized Mrd Quantification in European All Trials: Proceedings of the Second International Symposium on Mrd Assessment in Kiel, Germany, 18-20 September 2008', Leukemia, 24 (2010), 521-35.

M. Carlet, K. Janjetovic, J. Rainer, S. Schmidt, R. Panzer-Grumayer, G. Mann, M. Prelog, B. Meister, C. Ploner, and R. Kofler, 'Expression, Regulation and Function of Phosphofructo-Kinase/Fructose-Biphosphatases (Pfkfbs) in Glucocorticoid-Induced Apoptosis of Acute Lymphoblastic Leukemia Cells', BMC Cancer, 10 (2010), 638.

V. Conter, C. R. Bartram, M. G. Valsecchi, A. Schrauder, R. Panzer-Grumayer, A. Moricke, M. Arico, M. Zimmermann, G. Mann, G. De Rossi, M. Stanulla, F. Locatelli, G. Basso, F. Niggli, E. Barisone, G. Henze, W. D. Ludwig, O. A. Haas, G. Cazzaniga, R. Koehler, D. Silvestri, J. Bradtke, R. Parasole, R. Beier, J. J. van Dongen, A. Biondi, and M. Schrappe, 'Molecular Response to Treatment Redefines All Prognostic Factors in Children and Adolescents with B-Cell Precursor Acute Lymphoblastic Leukemia: Results in 3184 Patients of the Aieop-Bfm All 2000 Study', Blood, 115 (2010), 3206-14.

U. Creutzig, M. Zimmermann, M. Dworzak, C. Urban, G. Henze, B. Kremens, M. Lakomek, J. P. Bourquin, J. Stary, and D. Reinhardt, 'Favourable Outcome of Patients with Childhood Acute Promyelocytic Leukaemia after Treatment with Reduced Cumulative Anthracycline Doses', Br J Haematol, 149 (2010), 399-409.

C. Diakos, S. Zhong, Y. Xiao, M. Zhou, G. M. Vasconcelos, G. Krapf, R. F. Yeh, S. Zheng, M. Kang, J. K. Wiencke, M. S. Pombo-de-Oliveira, R. Panzer-Grumayer, and J. L. Wiemels, 'Tel-Aml1 Regulation of Survivin and Apoptosis Via Mirna-494 and Mirna-320a', Blood, 116 (2010), 4885-93.

M. N. Dworzak, G. Gaipa, A. Schumich, O. Maglia, R. Ratei, M. Veltroni, Z. Husak, G. Basso, L. Karawajew, H. Gadner, and A. Biondi, 'Modulation of Antigen Expression in B-Cell Precursor Acute Lymphoblastic Leukemia During Induction Therapy Is Partly Transient: Evidence for a Drug-Induced Regulatory Phenomenon. Results of the Aieop-Bfm-All-Flow-Mrd-Study Group', Cytometry B Clin Cytom, 78 (2010), 147-53.

S. Ehlers, C. Herbst, M. Zimmermann, N. Scharn, M. Germeshausen, N. von Neuhoff, C. M. Zwaan, K. Reinhardt, I. H. Hollink, J. H. Klusmann, T. Lehrnbecher, S. Roettgers, J. Stary, M. Dworzak, K. Welte, U. Creutzig, and D. Reinhardt, 'Granulocyte Colony-Stimulating Factor (G-Csf) Treatment of Childhood Acute Myeloid Leukemias That Overexpress the Differentiation-Defective G-Csf Receptor Isoform Iv Is Associated with a Higher Incidence of Relapse', J Clin Oncol, 28 (2010), 2591-7.

M. N. Gaze, T. Boterberg, K. Dieckmann, J. L. Habrand, S. Helfre, N. Peylan-Ramu, E. K. Chrzanowska, G. Schreier, and R. Ladenstein, 'Development of an Electronic Database for Quality Assurance of Radiotherapy in the International Society of Paediatric Oncology (Europe) High Risk Neuroblastoma Study', Radiother Oncol, 97 (2010), 593-5.

H. Gerr, M. Zimmermann, M. Schrappe, M. Dworzak, W. D. Ludwig, J. Bradtke, A. Moericke, R. Schabath, U. Creutzig, and D. Reinhardt, 'Acute Leukaemias of Ambiguous Lineage in Children: Characterization, Prognosis and Therapy Recommendations', Br J Haematol, 149 (2010), 84-92.

A. Handisurya, C. Schellenbacher, B. Reininger, F. Koszik, P. Vyhnanek, A. Heitger, R. Kirnbauer, and E. Forster-Waldl, 'A Quadrivalent Hpv Vaccine Induces Humoral and Cellular Immune Responses in Whim Immunodeficiency Syndrome', Vaccine, 28 (2010), 4837-41.

L. Hertzberg, E. Vendramini, I. Ganmore, G. Cazzaniga, M. Schmitz, J. Chalker, R. Shiloh, I. Iacobucci, C. Shochat, S. Zeligson, G. Cario, M. Stanulla, S. Strehl, L. J. Russell, C. J. Harrison, B. Bornhauser, A. Yoda, G. Rechavi, D. Bercovich, A. Borkhardt, H. Kempski, G. te Kronnie, J. P. Bourquin, E. Domany, and S. Izraeli, 'Down Syndrome Acute Lymphoblastic Leukemia, a Highly Heterogeneous Disease in Which Aberrant Expression of Crlf2 Is Associated with Mutated Jak2: A Report from the International Bfm Study Group', Blood, 115 (2010), 1006-17.

Z. Husak, D. Printz, A. Schumich, U. Potschger, and M. N. Dworzak, 'Death Induction by Cd99 Ligation in Tel/Aml1-Positive Acute Lymphoblastic Leukemia and Normal B Cell Precursors', J Leukoc Biol, 88 (2010), 405-12.

C. Hutter, A. Attarbaschi, S. Fischer, C. Meyer, M. Dworzak, M. Konig, R. Marschalek, G. Mann, O. A. Haas, and E. R. Panzer-Grumayer, 'Acute Monocytic Leukaemia Originating from Mll-Mllt3-Positive Pre-B Cells', Br J Haematol, 150 (2010), 621-3.

X. Jiang, Y. Gwye, D. Russell, C. Cao, D. Douglas, L. Hung, H. Kovar, T. J. Triche, and E. R. Lawlor, 'Cd133 Expression in Chemo-Resistant Ewing Sarcoma Cells', BMC Cancer, 10 (2010), 116.

B. Jurgens, D. Fuchs, J. Reichenbach, and A. Heitger, 'Intact Indoleamine 2,3-Dioxygenase Activity in Human Chronic Granulomatous Disease', Clin Immunol, 137 (2010), 1-4.

B. Jurgens, J. Raberger, D. Fuchs, and A. Heitger, 'Indoleamine 2,3-Dioxygenase in Human Hematopoietic Stem Cell Transplantation', Int J Tryptophan Res, 3 (2010), 77-90.

H. Kovar, 'Aurka Inhibitors: Right in Time', Pediatr Blood Cancer, 55 (2010), 3-4.

H. Kovar, 'Downstream Ews/Fli1 - Upstream Ewing's Sarcoma', Genome Med, 2 (2010), 8.

A. Kowalska, E. Bozsaky, and P. F. Ambros, 'Sequence-Based High Resolution Chromosomal Comparative Genomic Hybridization (Cgh)', Methods Mol Biol, 659 (2010), 299-312.

R. Ladenstein, U. Potschger, M. C. Le Deley, J. Whelan, M. Paulussen, O. Oberlin, H. van den Berg, U. Dirksen, L. Hjorth, J. Michon, I. Lewis, A. Craft, and H. Jurgens, 'Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-Ewing 99 Trial', J Clin Oncol, 28 (2010), 3284-91.

R. Ladenstein, D. Valteau-Couanet, P. Brock, I. Yaniv, V. Castel, G. Laureys, J. Malis, V. Papadakis, A. Lacerda, E. Ruud, P. Kogner, M. Garami, W. Balwierz, H. Schroeder, M. Beck-Popovic, G. Schreier, D. Machin, U. Potschger, and A. Pearson, 'Randomized Trial of Prophylactic Granulocyte Colony-Stimulating Factor During Rapid Cojec Induction in Pediatric Patients with High-Risk Neuroblastoma: The European Hr-Nbl1/Siopen Study', J Clin Oncol, 28 (2010), 3516-24.

C. Landlinger, S. Preuner, L. Baskova, M. van Grotel, N. G. Hartwig, M. Dworzak, G. Mann, A. Attarbaschi, L. Kager, C. Peters, S. Matthes-Martin, A. Lawitschka, M. M. van den Heuvel-Eibrink, and T. Lion, 'Diagnosis of Invasive Fungal Infections by a Real-Time Panfungal Pcr Assay in Immunocompromised Pediatric Patients', Leukemia, 24 (2010), 2032-8.

M. C. Le Deley, O. Delattre, K. L. Schaefer, S. A. Burchill, G. Koehler, P. C. Hogendoorn, T. Lion, C. Poremba, J. Marandet, S. Ballet, G. Pierron, S. C. Brownhill, M. Nesslbock, A. Ranft, U. Dirksen, O. Oberlin, I. J. Lewis, A. W. Craft, H. Jurgens, and H. Kovar, 'Impact of Ews-Ets Fusion Type on Disease Progression in Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: Prospective Results from the Cooperative Euro-E.W.I.N.G. 99 Trial', J Clin Oncol, 28 (2010), 1982-8.

T. Lion, K. Kosulin, C. Landlinger, M. Rauch, S. Preuner, D. Jugovic, U. Potschger, A. Lawitschka, C. Peters, G. Fritsch, and S. Matthes-Martin, 'Monitoring of Adenovirus Load in Stool by Real-Time Pcr Permits Early Detection of Impending Invasive Infection in Patients after Allogeneic Stem Cell Transplantation', Leukemia, 24 (2010), 706-14.

K. K. Matthay, B. Shulkin, R. Ladenstein, J. Michon, F. Giammarile, V. Lewington, A. D. Pearson, and S. L. Cohn, 'Criteria for Evaluation of Disease Extent by (123)I-Metaiodobenzylguanidine Scans in Neuroblastoma: A Report for the International Neuroblastoma Risk Group (Inrg) Task Force', Br J Cancer, 102 (2010), 1319-26.

A. L. Petzer, D. Wolf, D. Fong, T. Lion, I. Dyagil, Z. Masliak, A. Bogdanovic, L. Griskevicius, S. Lejniece, S. Goranov, L. Gercheva, A. Stojanovic, D. Peytchev, N. Tzvetkov, R. Griniute, R. Oucheva, H. Ulmer, M. Kwakkelstein, F. Rancati, and G. Gastl, 'High-Dose Imatinib Improves Cytogenetic and Molecular Remissions in Patients with Pretreated Philadelphia-Positive, Bcr-Abl-Positive Chronic Phase Chronic Myeloid Leukemia: First Results from the Randomized Celsg Phase Iii Cml 11 "Istahit" Study', Haematologica, 95 (2010), 908-13.

H. Pichler, A. Moricke, G. Mann, A. Teigler-Schlegel, F. Niggli, K. Nebral, M. Konig, A. Inthal, D. Krehan, M. N. Dworzak, D. Janousek, J. Harbott, M. Schrappe, H. Gadner, S. Strehl, O. A. Haas, R. Panzer-Grumayer, A. Attarbaschi, and Group Berlin-Frankfurt-Munster Study, 'Prognostic Relevance of Dic(9;20)(P11;Q13) in Childhood B-Cell Precursor Acute Lymphoblastic Leukaemia Treated with Berlin-Frankfurt-Munster (Bfm) Protocols Containing an Intensive Induction and Post-Induction Consolidation Therapy', Br J Haematol, 149 (2010), 93-100.

P. Rhein, R. Mitlohner, G. Basso, G. Gaipa, M. N. Dworzak, R. Kirschner-Schwabe, C. Hagemeier, M. Stanulla, M. Schrappe, W. D. Ludwig, L. Karawajew, and R. Ratei, 'Cd11b Is a Therapy Resistance- and Minimal Residual Disease-Specific Marker in Precursor B-Cell Acute Lymphoblastic Leukemia', Blood, 115 (2010), 3763-71.

A. Sander, M. Zimmermann, M. Dworzak, G. Fleischhack, C. von Neuhoff, D. Reinhardt, G. J. Kaspers, and U. Creutzig, 'Consequent and Intensified Relapse Therapy Improved Survival in Pediatric Aml: Results of Relapse Treatment in 379 Patients of Three Consecutive Aml-Bfm Trials', Leukemia, 24 (2010), 1422-8.

J. Santos, N. Cerveira, S. Bizarro, F. R. Ribeiro, C. Correia, L. Torres, S. Lisboa, J. Vieira, J. M. Mariz, L. Norton, S. Snijder, C. H. Mellink, A. Buijs, L. Y. Shih, S. Strehl, F. Micci, S. Heim, and M. R. Teixeira, 'Expression Pattern of the Septin Gene Family in Acute Myeloid Leukemias with and without Mll-Sept Fusion Genes', Leuk Res, 34 (2010), 615-21.

M. G. Seidel, E. Grohmann, K. Sadeghi, A. Pollak, A. Heitger, and E. Forster-Waldl, 'Vaccination against Tick-Borne Encephalitis Virus Tests Specific Igg Production Ability in Patients under Immunoglobulin Substitution Therapy', Vaccine, 28 (2010), 6621-6.

E. Sieczkowski, C. Lehner, P. F. Ambros, and M. Hohenegger, 'Double Impact on P-Glycoprotein by Statins Enhances Doxorubicin Cytotoxicity in Human Neuroblastoma Cells', Int J Cancer, 126 (2010), 2025-35.

M. Steiner, A. Attarbaschi, M. Dworzak, H. Strobl, W. Pickl, R. Kornmuller, O. Haas, H. Gadner, G. Mann, and Group Austrian Berlin-Frankfurt-Munster Study, 'Cytochemically Myeloperoxidase Positive Childhood Acute Leukemia with Lymphoblastic Morphology Treated as Lymphoblastic Leukemia', J Pediatr Hematol Oncol, 32 (2010), e4-7.

J. Stemberger, V. Witt, D. Printz, R. Geyeregger, and G. Fritsch, 'Novel Single-Platform Multiparameter Fcm Analysis of Apoptosis: Significant Differences between Wash and No-Wash Procedure', Cytometry A, 77 (2010), 1075-81.

C. T. Storlazzi, A. Lonoce, M. C. Guastadisegni, D. Trombetta, P. D'Addabbo, G. Daniele, A. L'Abbate, G. Macchia, C. Surace, K. Kok, R. Ullmann, S. Purgato, O. Palumbo, M. Carella, P. F. Ambros, and M. Rocchi, 'Gene Amplification as Double Minutes or Homogeneously Staining Regions in Solid Tumors: Origin and Structure', Genome Res, 20 (2010), 1198-206.

M. W. Traxlmayr, D. Wesch, A. M. Dohnal, P. Funovics, M. B. Fischer, D. Kabelitz, and T. Felzmann, 'Immune Suppression by Gammadelta T-Cells as a Potential Regulatory Mechanism after Cancer Vaccination with Il-12 Secreting Dendritic Cells', J Immunother, 33 (2010), 40-52.

P. Van Vlierberghe, T. Palomero, H. Khiabanian, J. Van der Meulen, M. Castillo, N. Van Roy, B. De Moerloose, J. Philippe, S. Gonzalez-Garcia, M. L. Toribio, T. Taghon, L. Zuurbier, B. Cauwelier, C. J. Harrison, C. Schwab, M. Pisecker, S. Strehl, A. W. Langerak, J. Gecz, E. Sonneveld, R. Pieters, E. Paietta, J. M. Rowe, P. H. Wiernik, Y. Benoit, J. Soulier, B. Poppe, X. Yao, C. Cordon-Cardo, J. Meijerink, R. Rabadan, F. Speleman, and A. Ferrando, 'Phf6 Mutations in T-Cell Acute Lymphoblastic Leukemia', Nat Genet, 42 (2010), 338-42.

C. von Neuhoff, D. Reinhardt, A. Sander, M. Zimmermann, J. Bradtke, D. R. Betts, Z. Zemanova, J. Stary, J. P. Bourquin, O. A. Haas, M. N. Dworzak, and U. Creutzig, 'Prognostic Impact of Specific Chromosomal Aberrations in a Large Group of Pediatric Patients with Acute Myeloid Leukemia Treated Uniformly According to Trial Aml-Bfm 98', J Clin Oncol, 28 (2010), 2682-9.

C. M. Zwaan, D. Reinhardt, M. Zimmerman, H. Hasle, J. Stary, B. Stark, M. Dworzak, U. Creutzig, G. J. Kaspers, and B. F. M. Study Group on Paediatric A. M. L. International, 'Salvage Treatment for Children with Refractory First or Second Relapse of Acute Myeloid Leukaemia with Gemtuzumab Ozogamicin: Results of a Phase Ii Study', Br J Haematol, 148 (2010), 768-76.