The CCRI's approach includes basic, translational and clinical research for the benefit of children with cancer.
- Research Areas
The CCRI's research areas include leukaemias, solid tumours, immunology, molecular microbiology and clinical research.
- Leukaemias
- Immunological Diagnostics
We aim at developing and evaluating new diagnostic, prognostic and therapeutic approaches for paediatric leukaemias using high-end multi-colour flow cytometry.
- Biology of Leukaemias
Understanding leukaemia pathogenesis not only allows us to gain exciting new insights into the biology of this disease but, even more importantly, to identify novel biomarkers and potential targets for future specific therapies.
- Genetics of Leukaemias
Tracking down the faulty genes that cause leukaemia with the ultimate goal to establish predictive biomarkers for the optimisation of risk-adapted therapy.
- Solid Tumours
- Tumour Biology
We aim to establish, validate and apply new diagnostic and therapeutic tools to facilitate personalised treatment of children with malignant tumours.
- Molecular Biology of Solid Tumours
To increase therapeutic efficacy while decreasing side effects, we have to specifically target the Achille`s heel of the disease.
- Immunology
- Tumour Immunology
The last decades brought enormous progress in our understanding of the cellular and molecular biology of cancerous disease. One of the areas of hope is cancer immune therapy. We work on concepts for manipulating the immune system in order to trigger anti-tumour immunity, which has the capacity to control the growth of cancer cells.
- Clinical Cell Biology and FACS Core Unit
With our engagement in flow cytometry and GMP-compliant work, we are a supportive interface between research and therapy.
- Transplantation-Immunology
To better understand the immune system’s foundation, its organisation and dynamic regulation particularly with respect to transplantation tolerance poses a valuable challenge.
- Molecular Microbiology
- Molecular Microbiology
Our group primarily focuses on the improvement of treatment outcomes, particularly in transplant recipients and patients with life-threatening infections, by developing and implementing new diagnostic technologies.
- Clinical Research
- Studies & Statistics for Integrated Research and Projects
Multinational networking is fundamental for clinical research of malignant cancer in children and adolescents. Only controlled large-scale clinical trials allow improving complex treatment strategies, whilst smaller studies allow testing innovative drug medications to further improve survival rates. The clinical trail unit S2IRP undertakes all efforts to serve the complex tasks of clinical trial management.
- Research Groups
Read more about the broad range of outstanding work conducted by our researchers.
- Projects & Science Events
Welcome to our menu "Events and Science" and read more about our research projects and scientific events.
- Core Facilities
The CCRI offers three main Core Units to support its researchers and to provide external services: FACS Core Unit, Bioinformatics Unit and Quality Management Unit.
- FACS Core Unit
The Laboratory for Clinical Cell Biology and FACS Core Unit optimised flow cytometric measurements and established routine tools to provide information to clinicians about stem cells as well as all other blood leukocytes.
- Bioinformatics
The Bioinformatics Unit works at the interface of molecular biology and bioinformatics. The BU supports CCRI researchers with the analysis, integration and interpretation of large scale genomics data. Custom analyses of array or sequencing based platforms are provided. Primary data analyses are performed by the application of state-of-the art tools. Established connections with bioinformatic collaborators facilitate access to the newest technologies.
- Quality Management
The Quality Management facility of CCRI has been developing a quality management system according to good clinical practice (GCP) for clinical trials, since CCRI acts as a sponsor for clinical trials conducted in the St. Anna Children's Hospital in collaboration with other paediatric oncology clinics worldwide.
- Science Events
Welcome to our menu "Events and Science" and read more about our research projects and scientific events.
- Grants
- Collaborations
The CCRI has successfully managed to establish a wide network consisting of national and international partners collaborating with our scientists and clinicians at the St. Anna Children’s hospital on biomedical research projects and clinical studies for various childhood cancers. As a result, our predominantly charity-based organisation can gain access to and share the most recent cost-intensive technologies.
- Publications
Consult through a customised search all scientific publications arising from work performed at CCRI or in collaboration with external researchers.
- Scientific Reports
The CCRI Scientific Reports document our research activities, major achievements and facts and figures during the past few years.
