• The Institute
    • Mission

      CCRI’s scientists aim to make the most innovative treatment options available to young cancer patients.

    • At a Glance

      The CCRI has developed into the largest centre for research related to childhood cancer in Austria.

    • History & Future

      In January 2009, the CCRI moved to a newly built independent research institute, located in 1090 Vienna.

      • Future

        CCRI strives to get access to the newest genomic technologies and implement holistic approaches to a better understanding of paediatric cancers

    • Organisation

      The CCRI's organisational structure at a glance

    • Scientific Advisory Board

      To ensure international standards and high-quality performance, the CCRI submits its activities to regular reviews.

    • Facts and Figures

      The Children's Cancer Research Institute and its activities at a glance

  • Research

    The CCRI's approach includes basic, translational and clinical research for the benefit of children with cancer.

    • Research Areas

      The CCRI's research areas include leukaemias, solid tumours, immunology, molecular microbiology and clinical research.

      • Leukaemias
        • Immunological Diagnostics

          We aim at developing and evaluating new diagnostic, prognostic and therapeutic approaches for paediatric leukaemias using high-end multi-colour flow cytometry.

        • Biology of Leukaemias

          Understanding leukaemia pathogenesis not only allows us to gain exciting new insights into the biology of this disease but, even more importantly, to identify novel biomarkers and potential targets for future specific therapies.

        • Genetics of Leukaemias

          Tracking down the faulty genes that cause leukaemia with the ultimate goal to establish predictive biomarkers for the optimisation of risk-adapted therapy.

      • Solid Tumours
        • Tumour Biology

          We aim to establish, validate and apply new diagnostic and therapeutic tools to facilitate personalised treatment of children with malignant tumours.

        • Molecular Biology of Solid Tumours

          To increase therapeutic efficacy while decreasing side effects, we have to specifically target the Achille`s heel of the disease.

        • Epigenome-based precision medicine

          To increase therapeutic efficacy while decreasing side effects, we have to specifically target the Achille`s heel of the disease.

      • Immunology
        • Development of Cellular Therapeutics

          Adoptive immunotherapy based on the transfer of T cells modified with CARs has recently been proven in clinical studies to mediate impressive regression and even cure of tumors. Thus, the approach is currently one of the most promising forms of cancer immunotherapy. Our prime goal is to establish new immunotherapeutic options based on CAR-modified T cells for several paediatric malignancies, such as the different types of sarcomas, glioma and certain types of leukemia. Additionally, we hypothesize that the CAR-approach could also be adapted for the treatment of infections with Cytomegalovirus (CMV), which is still a major complication in transplant patients.

        • Clinical Cell Biology and FACS Core Unit

          With our engagement in flow cytometry and GMP-compliant work, we are a supportive interface between research and therapy.

      • Molecular Microbiology
        • Molecular Microbiology

          Our group primarily focuses on the improvement of treatment outcomes, particularly in transplant recipients and patients with life-threatening infections, by developing and implementing new diagnostic technologies.

      • Clinical Research
        • Studies & Statistics for Integrated Research and Projects

          Multinational networking is fundamental for clinical research of malignant cancer in children and adolescents. Only controlled large-scale clinical trials allow improving complex treatment strategies, whilst smaller studies allow testing innovative drug medications to further improve survival rates. The clinical trail unit S2IRP undertakes all efforts to serve the complex tasks of clinical trial management.

      • Langerhans Cell Histiocytosis (LCH)

        zebrafish is used (danio rerio) to model pediatric cancers (leukemia and solid tumors) and rare cancer predisposition syndromes. Using cutting-edge genetic modeling approaches combined with state of the art in vivo imaging we aim to dissect the molecular mechanisms, which govern tumor onset and tumor progression. Our genetic models are also employed in our lab for drug screening to identify potential therapeutic strategies. We further use our models to better understand the role of the innate immune system at early tumor initiating stages.

        • Pathobiology of LCH

          To increase therapeutic efficacy while decreasing side effects, we have to specifically target the Achille`s heel of the disease.

      • Innovative Cancer Models

        zebrafish is used (danio rerio) to model pediatric cancers (leukemia and solid tumors) and rare cancer predisposition syndromes. Using cutting-edge genetic modeling approaches combined with state of the art in vivo imaging we aim to dissect the molecular mechanisms, which govern tumor onset and tumor progression. Our genetic models are also employed in our lab for drug screening to identify potential therapeutic strategies. We further use our models to better understand the role of the innate immune system at early tumor initiating stages.

        • Innovative Cancer Models

          To increase therapeutic efficacy while decreasing side effects, we have to specifically target the Achille`s heel of the disease.

    • Research Groups

      Read more about the broad range of outstanding work conducted by our researchers.

    • Projects & Science Events

      Welcome to our menu "Events and Science" and read more about our research projects and scientific events.

    • Core Facilities

      The CCRI offers three main Core Units to support its researchers and to provide external services: FACS Core Unit, Bioinformatics Unit and Quality Management Unit.

      • FACS Core Unit

        The Laboratory for Clinical Cell Biology and FACS Core Unit optimised flow cytometric measurements and established routine tools to provide information to clinicians about stem cells as well as all other blood leukocytes.

      • Bioinformatics

        The Bioinformatics Unit works at the interface of molecular biology and bioinformatics. The BU supports CCRI researchers with the analysis, integration and interpretation of large scale genomics data. Custom analyses of array or sequencing based platforms are provided. Primary data analyses are performed by the application of state-of-the art tools. Established connections with bioinformatic collaborators facilitate access to the newest technologies.

      • Quality Management

        The Quality Management facility of CCRI has been developing a quality management system according to good clinical practice (GCP) for clinical trials, since CCRI acts as a sponsor for clinical trials conducted in the St. Anna Children's Hospital in collaboration with other paediatric oncology clinics worldwide.

    • Grants
    • Collaborations

      The CCRI has successfully managed to establish a wide network consisting of national and international partners collaborating with our scientists and clinicians at the St. Anna Children’s hospital on biomedical research projects and clinical studies for various childhood cancers. As a result, our predominantly charity-based organisation can gain access to and share the most recent cost-intensive technologies.

    • Publications

      Consult through a customised search all scientific publications arising from work performed at CCRI or in collaboration with external researchers.

    • Scientific Reports

      The CCRI Scientific Reports document our research activities, major achievements and facts and figures during the past few years.

  • Careers
    • Working at the CCRI

      The people at CCRI are engaged in the mission of performing world-renowned research dedicated to improving human health. The institute focuses essentially in experimental research but the close contact with clinical groups makes of CCRI a very stimulating place to translate basic findings from bench to bedside.

    • Education

      The CCRI offers diploma and PhD positions for students of the life sciences or medicine in co-operation with the University of Vienna and the Medical University of Vienna.

    • Job Openings

      This section is dedicated to the announcement of open positions at CCRI. In case there are no open positions announced, CCRI still invites interested applicants to regularly visit the website and to send an updated CV and letter of motivation to personal@ccri.at.

      • PhD Thesis Opportunity

        The “Innovative Cancer Models” group at the Children’s Cancer Research Institute (CCRI) in Vienna is looking for a highly motivated student interested in carrying out a PhD Thesis project (http://science.ccri.at/research/research-areas/innovative-cancer-models/). Our lab is using zebrafish cancer models to better understand disease onset and progression and to identify novel therapeutic strategies for pediatric cancer. The zebrafish model offers two unique opportunities here: live microscopy as zebrafish larvae are transparent and easy drug screening as compounds are taken up by zebrafish larvae from the surrounding water. The aim of this PhD project will be to improve cancer modeling in zebrafish by adapting cutting-edge technologies like opto-genetics for this purpose. The CCRI is equipped with a large zebrafish facility, an automated zebrafish drug screening platform (Zebrafish platform Austria for preclinical drug screening - ZANDR) and state-of-the-art confocal and light-sheet microscopes. The position is available immediately and should ideally be filled by September 2018. Successful applicants will be offered a salary according to the Austrian Science Fund standards (https://www.fwf.ac.at/en/research-funding/personnel-costs/ ). If you are interested in this topic, please send an application including your CV, a letter of motivation and the name of 2 referees to Martin Distel, email: personal@ccri.at by June 1st 2018. The institution: The CCRI is part of a flourishing biomedical research hub at the heart of beautiful Vienna, a European metropolis full of history, music and fine arts. Vienna has been voted “most livable” city in the world for the 4th year in a row. CCRI is a renowned research institution with tight links to the St. Anna Children's Hospital, a leading pediatric cancer center in Europe well connected through various European and international networks. CCRI seeks to advance the diagnosis and treatment of children’s cancers through basic, translational and clinical research, in research areas such as cancer biology, immunology, and genetics/epigenetics (http://science.ccri.at/).

      • Clinical Platform Manager
      • Master thesis
      • Research Scientist – Clinical Tumor Genomics/Diagnostics
      • Senior Bioinformatician
      • Fully Funded PhD Student Position: Epigenome-based Precision Medicine
      • Pediatric leukemia Principal Investigator & Clinical Geneticist
      • Fachärtzin/-arzt für Kinder- u. Jugendheilkunde mit wiss. Interesse (Hämatologie und Onkologie)
    • Alumni

      The Alumni section is dedicated to former CCRI workers that continued to pursued successful careers after they left the institute.

    • Living and working in Vienna
  • Public
    • Science Communications

      We aim to communicate scientific issues to society in an easy-to-understand way by developing efficient measures.

    • News & Events

      Our news and public events are dedicated to bring the general public and various stakeholders the latest information on burning issues and the CCRI's research activities.

    • Press Corner

      Welcome to the CCRI's press corner dedicated to journalists and media professionals.

    • Support Us

      The CCRI is mainly funded through private donations to the Association St. Anna Kinderkrebsforschung e.V.

  • Contact us
    • Contact Details

      Contact data of the CCRI's staff

    • How to Find Us

      You can easily reach us via public transport. To make sure you will find us without any problems, you may download directional maps in the enclosed pdf files.

    • Sitemap
    • Imprint

      The CCRI strives to provide correct and up-to-date information through this web site. It does not take liability for any damages resulting from incorrect or outdated contents; nor for any action resulting from the use of contents.